2025
P-623 MFF is required for mitochondria-associated ribonucleoprotein domain coalescence and mRNA translation in mammalian oocytes
Hua R, Zhuo H, Gu J, Du H, Xiao Y, Yeung W, Wang T. P-623 MFF is required for mitochondria-associated ribonucleoprotein domain coalescence and mRNA translation in mammalian oocytes. Human Reproduction 2025, 40: deaf097.929. DOI: 10.1093/humrep/deaf097.929.Peer-Reviewed Original ResearchMitochondrial fission factorMitochondrial membrane potentialRNA-binding proteinsMammalian oocytesMouse oocytesMRNA translational activityMRNA translationGerminal vesicle (GV)-stage oocytesCo-IPMitochondrial dynamicsOocyte meiotic maturationRegulation of mitochondrial dynamicsMetaphase I stageTranslational activityGV stageGV oocytesRegulation of translationJC-1 stainingATP metabolic processRegulate mRNA translationWestern blot analysisGene ontology analysisMeiotic maturationWider implicationsOocyte maturationNeuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators
Malone T, Wu J, Zhang Y, Licznerski P, Chen R, Nahiyan S, Pedram M, Jonas E, Kaczmarek L. Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators. Science Advances 2025, 11: eadv3140. PMID: 40435242, PMCID: PMC12118559, DOI: 10.1126/sciadv.adv3140.Peer-Reviewed Original ResearchConceptsMRNA translationTranslational regulationInitiation of mRNA translationInitiation of translationSevere intellectual disabilityRegulation of translationMRNA translation regulationNeurites of cortical neuronsB-actinChannel activityIntellectual disabilityPotassium channel activityNeuronal activityMolecular mechanismsInhibit initiationMutationsCell linesPharmacological stimulationCortical neuronsMRNABindingRegulationTranslationEIF4ECYFIP1
2024
Unraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid Malignancies
Biancon G, Busarello E, Cheng M, Sidoli S, VanOudenhove J, Bucciarelli G, Tebaldi T, Halene S. Unraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid Malignancies. Blood 2024, 144: 4117. DOI: 10.1182/blood-2024-211265.Peer-Reviewed Original ResearchRNA-binding proteinsStress granulesRNA-seqArsenite stressSF mutationsAcute myeloid leukemiaSplicing factorsSG proteinsStress responseClonal advantageSG coresMulti-OmicsDeregulated genesMyelodysplastic syndromeEnhances SG formationU2AF1 S34F mutationSingle-cell RNA-seqWT cellsMegakaryocyte-erythroid progenitorsRegulation of translationTranslation initiation factorsImprove cell fitnessRNA-seq analysisPost-translational modificationsU2AF1 mutations
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