2025
P-623 MFF is required for mitochondria-associated ribonucleoprotein domain coalescence and mRNA translation in mammalian oocytes
Hua R, Zhuo H, Gu J, Du H, Xiao Y, Yeung W, Wang T. P-623 MFF is required for mitochondria-associated ribonucleoprotein domain coalescence and mRNA translation in mammalian oocytes. Human Reproduction 2025, 40: deaf097.929. DOI: 10.1093/humrep/deaf097.929.Peer-Reviewed Original ResearchMitochondrial fission factorMitochondrial membrane potentialRNA-binding proteinsMammalian oocytesMouse oocytesMRNA translational activityMRNA translationGerminal vesicle (GV)-stage oocytesCo-IPMitochondrial dynamicsOocyte meiotic maturationRegulation of mitochondrial dynamicsMetaphase I stageTranslational activityGV stageGV oocytesRegulation of translationJC-1 stainingATP metabolic processRegulate mRNA translationWestern blot analysisGene ontology analysisMeiotic maturationWider implicationsOocyte maturation
1998
Activin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
Alak B, Coskun S, Friedman C, Kennard E, Kim M, Seifer D. Activin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro. Fertility And Sterility 1998, 70: 1126-1130. PMID: 9848305, DOI: 10.1016/s0015-0282(98)00386-0.Peer-Reviewed Original ResearchConceptsGranulosa cell steroidogenesisGerminal vesicle breakdownGranulosa cellsActivin AE2 secretionSteroid secretionCell steroidogenesisNonluteinized granulosa cellsMeiotic maturationMetaphase IIUniversity Medical CenterAntral granulosa cellsNonovarian pathologyInhibin AMedical CenterMAIN OUTCOMEActivin A.Oocyte meiotic maturationImmature oocytesHuman oocytesOocyte maturationSecretionVesicle breakdownProgesteroneSteroidogenesis
1983
Regulation of mouse oocyte meiotic maturation: Implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis
Schultz R, Montgomery R, Belanoff J. Regulation of mouse oocyte meiotic maturation: Implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis. Developmental Biology 1983, 97: 264-273. PMID: 6189752, DOI: 10.1016/0012-1606(83)90085-4.Peer-Reviewed Original ResearchConceptsGerminal vesicle breakdownOocyte cAMPResumption of meiosisOocyte cAMP concentrationMeiotic maturationCumulus cell-oocyte complexesLevels of cAMPCAMP phosphodiesterase inhibitorDbcAMP-containing mediumAntral folliclesPreovulatory antral folliclesPhosphodiesterase inhibitorOocyte meiotic maturationCumulus cellsMouse oocyte meiotic maturationCAMP levelsVesicle breakdownCAMP concentrationDibutyryl cAMPBiochemical changesIBMXPeriod of timePossible roleFolliclesOocytes
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