Jeans Miguel Santana, MD
he/him/his
Assistant Professor of AnesthesiologyCards
About
Research
Publications
2022
Mechanical Circulatory Support Options in Patients With Aortic Valve Pathology.
Santana JM, Dalia AA, Newton M, Pisano DV, Eapen S, Kawabori M, Ortoleva J. Mechanical Circulatory Support Options in Patients With Aortic Valve Pathology. Journal Of Cardiothoracic And Vascular Anesthesia 2022, 36: 3318-3326. PMID: 35545462, DOI: 10.1053/j.jvca.2022.04.010.Peer-Reviewed Original ResearchProthrombin complex concentrates in cardiac surgery: where are we?
Santana JM, Brovman EY. Prothrombin complex concentrates in cardiac surgery: where are we? Current Opinion In Anaesthesiology 2022, 35: 36-41. PMID: 34669612, DOI: 10.1097/ACO.0000000000001074.Peer-Reviewed Original ResearchIntraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion.
Santana JM, Rosell FM, Dave B, El Manafi A. Intraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion. Annals Of Cardiac Anaesthesia 2022, 25: 77-80. PMID: 35075025, PMCID: PMC8865348, DOI: 10.4103/aca.ACA_192_20.Peer-Reviewed Original Research
2019
Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency
Hashimoto T, Isaji T, Hu H, Yamamoto K, Bai H, Santana JM, Kuo A, Kuwahara G, Foster TR, Hanisch JJ, Yatsula BA, Sessa WC, Hoshina K, Dardik A. Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 754-764. PMID: 30786746, PMCID: PMC6436985, DOI: 10.1161/atvbaha.119.312417.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, AbdominalArteriovenous Shunt, SurgicalCaveolaeCaveolin 1Cells, CulturedDrug Evaluation, PreclinicalHemorheologyHumansLungMaleMiceMice, Inbred C57BLMice, KnockoutNitric OxideNitric Oxide Synthase Type IIIPeptide FragmentsReceptor, EphB4Signal TransductionVascular RemodelingVena Cava, InferiorConceptsCav-1 KO miceAVF maturationWT miceAVF patencyEph-B4KO miceCav-1 functionCav-1Mouse aortocaval fistula modelEphrin-B2/FcArteriovenous fistula patencyAortocaval fistula modelCaveolin-1 SignalingFistula environmentCav-1 mRNAFistula patencyHET miceVenous adaptationEndothelial cell membraneENOS activityFistula modelRC miceControl veinsWall thickeningMice
2018
High-density lipoprotein carbamylation and dysfunction in vascular disease.
Santana JM, Brown CD. High-density lipoprotein carbamylation and dysfunction in vascular disease. Frontiers In Bioscience (Landmark Edition) 2018, 23: 2227-2234. PMID: 29772557.Peer-Reviewed Original ResearchCLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues
Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC. CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. Journal Of Biological Chemistry 2018, 293: 9126-9136. PMID: 29588368, PMCID: PMC5995495, DOI: 10.1074/jbc.ra117.000773.Peer-Reviewed Original ResearchConceptsCircadian locomotor output cycles kaputCLOCK phosphorylationCircadian gene expressionPhosphorylation sitesGene expressionNovel phosphorylation sitesClock-controlled genesCRISPR/Cas9 technologyNovel Akt substrateE-box elementsCore circadian genesAkt substrateTranscription factorsE-boxCentral circadian rhythmNuclear localizationNegative regulatorCas9 technologyNuclear accumulationCircadian genesInsulin-sensitive tissuesNuclear translocationPhosphorylationExpression levelsSer-845
2017
Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency
Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A. Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency. Scientific Reports 2017, 7: 15386. PMID: 29133876, PMCID: PMC5684317, DOI: 10.1038/s41598-017-13071-2.Peer-Reviewed Original ResearchConceptsEphrin-B2/FcVenous remodelingAVF maturationFistula patencyEph-B4Knockout miceMouse aortocaval fistula modelAkt1 knockout miceArteriovenous fistula patencyAortocaval fistula modelArteriovenous fistula maturationFistula environmentFistula useFistula veinAVF patencyFistula diameterFistula maturationVenous adaptationFistula modelWall thicknessPatencyProtein expressionAKT1 expressionEphrin-B2Lower ratesAkt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression
Luciano AK, Santana JM, Velazquez H, Sessa WC. Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. Journal Of Biological Rhythms 2017, 32: 212-221. PMID: 28452287, PMCID: PMC5703205, DOI: 10.1177/0748730417704534.Peer-Reviewed Original ResearchConceptsCircadian gene expressionCircadian regulatorsAmplitude of expressionGene expressionAkt isoformsIsoforms of AktCircadian transcriptionOrganismal levelPositive regulatorNormal behavioral rhythmsCircadian rhythmPeripheral clocksBehavioral rhythmsAKT1RegulatorAktIsoformsMammalsAmplitude rhythmsDaily rhythmsDifferent functionsLow-amplitude rhythmExpressionEndothelial cellsMice exhibitImproving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?
Isaji T, Hashimoto T, Yamamoto K, Santana JM, Yatsula B, Hu H, Bai H, Jianming G, Kudze T, Nishibe T, Dardik A. Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries? Annals Of Vascular Diseases 2017, 10: ra.17-00008. PMID: 29034014, PMCID: PMC5579803, DOI: 10.3400/avd.ra.17-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial nitric oxide synthaseVein graftsVein graft failureGraft failureEph-B4Endothelial cellsCritical limb ischemiaAutogenous vein graftsNitric oxide synthaseGold standard conduitNovel therapeutic targetMouse vein graftsVein graft wallExcessive neointimal hyperplasiaVein graft adaptationVenous endothelial cellsPREVENT trialArterial environmentGraft outcomeLimb ischemiaAdequate dilationArterial bypassOxide synthaseVascular surgeonsNeointimal hyperplasiaPatch Angioplasty in the Rat Aorta or Inferior Vena Cava.
Bai H, Li X, Hashimoto T, Hu H, Foster TR, Hanisch JJ, Santana JM, Dardik A. Patch Angioplasty in the Rat Aorta or Inferior Vena Cava. Journal Of Visualized Experiments 2017 PMID: 28287579, PMCID: PMC5409337, DOI: 10.3791/55253.Peer-Reviewed Original ResearchConceptsInferior vena cavaPatch angioplastyPericardial patchVena cavaNeointimal hyperplasiaInfrarenal inferior vena cavaInfra-renal IVCPericardial patch angioplastyPostoperative day 7Bovine pericardial patchWeek-old Wistar ratsPatch arterioplastyVenous patchArterial patchPatch venoplastyVascular surgeryRat aortaRat modelWistar ratsNeointimal thicknessDay 7Nylon suturesAngioplastyAortaVenous environment
Academic Achievements & Community Involvement
Clinical Care
Overview
Clinical Specialties
Anesthesiology; Cardiac Anesthesiology
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 2023