Helene Benveniste, MD, PhD
Anthony N. Brady Professor of AnesthesiologyCards
Appointments
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
About
Titles
Anthony N. Brady Professor of Anesthesiology
Biography
Dr. Benveniste is a Professor of Anesthesiology at Yale. She received her Bachelors degree in Mathematics & Physics from Katedralskolen, Denmark, and went on to study at the University of Copenhagen, where she received her MD in 1989 and PhD (Doctor Medicinae) in 1991. As a Research Fellow, she trained in high field magnetic resonance imaging (MRI) at Duke University Medical Center with Dr. G. Allen Johnson and developed techniques for brain imaging focused on neurodegenerative disease processes, including Alzheimer’s Disease. She went on to pursue her internship training in Family Medicine and her residency in Anesthesiology also at Duke University. Dr. Benveniste joined the faculty of Duke University's department of Anesthesiology in 1996, where she continued her work in developing diagnostic MRI based platforms for early detection of AD.
In 2001 Dr. Benveniste joined the department of Anesthesiology at Stony Book Medical Center as faculty and set up a preclinical MRI facility at Brookhaven National Laboratory; PET technology was integrated into her work to measure the bioavailability and pharmacokinetics of psychoactive compounds and anesthetic drugs. In 2015, Dr. Benveniste’s laboratory became involved with studies of the ‘glymphatic pathway’ which is a novel peri-vascular based system in the central nervous system involved in brain waste removal. Dr. Benveniste has received national and international recognition for her work. In November of 2016, Benveniste moved to Yale University, where she joined the Department of Anesthesiology and is expanding her research program in understanding how the glymphatic system and cerebrospinal fluid transport is affected in neurodegenerative disease states and aging.
Appointments
Anesthesiology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Copenhagen, Neurobiology (1991)
- MD
- University of Copenhagen (1986)
Research
Overview
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Sunil Koundal
Hedok Lee
Zachary Gursky, PhD
Burhan Ozturk, MD
Douglas Rothman, PhD
D. S. Fahmeed Hyder, PhD
Brain
Central Nervous System
Anesthesia
Publications
2025
3 Cerebrospinal Fluid
Al Bizri E, Benveniste H. 3 Cerebrospinal Fluid. 2025, 67-76. DOI: 10.1016/b978-0-323-93273-8.00003-1.Peer-Reviewed Original Research
2024
Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease
Koundal S, Chen X, Gursky Z, Lee H, Xu K, Liang F, Xie Z, Xu F, Lin H, Van Nostrand W, Gu X, Elkin R, Tannenbaum A, Benveniste H. Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease. IScience 2024, 111463. DOI: 10.1016/j.isci.2024.111463.Peer-Reviewed Original ResearchAltmetricIs CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
van Veluw S, Benveniste H, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A, van Osch M. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cellular And Molecular Life Sciences 2024, 81: 239. PMID: 38801464, PMCID: PMC11130115, DOI: 10.1007/s00018-024-05277-1.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsA translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy
van Veluw S, Benveniste H, van Osch M, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A. A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy. European Heart Journal 2024, 45: 1500-1502. PMID: 38289319, DOI: 10.1093/eurheartj/ehae011.Peer-Reviewed Original ResearchCitationsAltmetricUnbalanced regularized optimal mass transport with applications to fluid flows in the brain
Chen X, Benveniste H, Tannenbaum A. Unbalanced regularized optimal mass transport with applications to fluid flows in the brain. Scientific Reports 2024, 14: 1111. PMID: 38212659, PMCID: PMC10784574, DOI: 10.1038/s41598-023-50874-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFluid flowMass transportEntire transport processNumerical solution procedureKinetic energyTotal kinetic energyImage trackingSolution procedureOptimal mass transportTransport processesMass transport approachTransport problemsMass configurationConstraint equationsFlowTransport approachApplicationsBenamouFormulationTransportTrackingCerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments
Schrader J, Majchrzak M, Xu F, Lee H, Agostinucci K, Davis J, Benveniste H, Van Nostrand W. Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments. Neuroscience Insights 2024, 19: 26331055241288172. PMID: 39386146, PMCID: PMC11462563, DOI: 10.1177/26331055241288172.Peer-Reviewed Original ResearchAltmetricConceptsCerebral amyloid angiopathyPathogenesis of cerebral amyloid angiopathyTGF-b1Rat modelTGF-b1 levelsType 2Few proteinsSmooth muscle cell lossTransforming growth factor beta 1Wild-type ratsProteomic changesB proteinProteomic analysisPeptidase ATransgenic rat modelPathway analysisMolecular insightsMagnetic resonance imagingCognitive impairmentAlzheimer's diseaseCell lossAmyloid depositsRatsAmyloid angiopathyCortical microhemorrhages
2023
Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries. Nature Aging 2023, 3: 1603-1603. PMID: 38001312, DOI: 10.1038/s43587-023-00544-5.Peer-Reviewed Original ResearchAltmetricVisualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience
Chen X, Tran A, Elkin R, Benveniste H, Tannenbaum A. Visualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience. Journal Of Scientific Computing 2023, 97: 26. PMID: 38938875, PMCID: PMC11210720, DOI: 10.1007/s10915-023-02337-9.Peer-Reviewed Original ResearchCitationsConceptsMass transport problemFluid flowOptimal mass transport problemComputational fluid dynamicsTransport problemsFluid dynamicsMass transportPrevious numerical methodsDynamic formulationOptimal mass transportContinuity equationNumerical methodNumerical resultsDiffusion termPresent workComputational runtimeFlowEfficient implementationBrenierBenamouContinuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRatsNeurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2
DiNuzzo M, Dienel G, Behar K, Petroff O, Benveniste H, Hyder F, Giove F, Michaeli S, Mangia S, Herculano‐Houzel S, Rothman D. Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2. Journal Of Neurochemistry 2023, 168: 632-662. PMID: 37150946, PMCID: PMC10628336, DOI: 10.1111/jnc.15839.Peer-Reviewed Original ResearchCitationsAltmetricConceptsHigher cerebral blood flowCerebral blood flowOxygen extraction fractionNeurovascular couplingBlood flowLower oxygen extraction fractionNonoxidative glycolysisCerebral metabolic rateBrain pHCapillary densityNeurovascular diseasesNonoxidative metabolismTissue oxygenationHuman cortexBrain functionExtraction fractionBrain activationMitochondrial ATP productionPET measurementsCMROOxygen consumptionHomeostasisGlycogenolysisFMRI contrastActivation
News
News
- March 06, 2022Source: YaleNews
Waste Management in the Brain May Shed Light on Dementia
- July 05, 2020
Sleep: memory's careful custodian
- February 04, 2020
The Departments of Anesthesiology and Neurology Host: “Perivascular Spaces in the Brain & Contributions to Pathology of Cerebral Small Vessel Disease” on March 24
- September 17, 2018
Nora D. Volkow, MD, Director of the National Institute on Drug Abuse, to Keynote Third Annual Anesthesiology Department Research Retreat, Oct. 5-6
Get In Touch
Contacts
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
Locations
Tompkins Memorial Pavilion
Academic Office
789 Howard Avenue, Fl 3rd, Rm 332
New Haven, CT 06519