Elizabeth Eynon, PhD
Research Scientist in Immunobiology; Chair, IACUC
Research & Publications
Biography
News
Extensive Research Description
My current reseach involves characterization of mice that support human cells and tissues. These mice have been generated in the Flavell lab to have transgenic expression of human genes used to support correct expression and differentiation mostly of cells of the immune system when transplanted into these model mice.
Research Interests
Autoimmune Diseases
Selected Publications
- Efficient differentiation and function of human macrophages in humanized CSF-1 miceRathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 2011, 118: 3119-3128. PMID: 21791433, DOI: 10.1182/blood-2010-12-326926.
- Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized miceStrowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA. Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 13218-13223. PMID: 21788509, PMCID: PMC3156175, DOI: 10.1073/pnas.1109769108.
- Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivoRongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2378-2383. PMID: 21262827, PMCID: PMC3038726, DOI: 10.1073/pnas.1019524108.
- Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lungWillinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2390-2395. PMID: 21262803, PMCID: PMC3038773, DOI: 10.1073/pnas.1019682108.
- The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsivenessHawiger D, Wan YY, Eynon EE, Flavell RA. The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness. Nature Immunology 2010, 11: 962-968. PMID: 20802482, PMCID: PMC2943559, DOI: 10.1038/ni.1929.