Sylvie Dufour
Associate Research Scientist (Endocrinology)Cards
About
Research
Publications
2026
2503-P: The Noradrenergic System Regulates Hepatic Gluconeogenesis, Mitochondrial Oxidation, and Autophagy by CaMKII during Cold Exposure
MORGAN H, GASPAR R, SCHAVINSKI A, ASSIS A, ZHENG J, PARIKH S, DUFOUR S, KAHN M, NASIRI A, PERELIS M, KETTELHUT I, NAVEGANTES L, SHULMAN G. 2503-P: The Noradrenergic System Regulates Hepatic Gluconeogenesis, Mitochondrial Oxidation, and Autophagy by CaMKII during Cold Exposure. Diabetes 2026, 75 DOI: 10.2337/db26-2503-p.Peer-Reviewed Original ResearchHepatic mitochondrial metabolismMitochondrial oxidationHepatic mitochondrial oxidationConversion to glucoseMitochondrial metabolismAntisense oligonucleotidesSao Paulo Research FoundationCold exposureMolecular mechanismsActivation of CaMKIIHepatic gluconeogenesisRate of glycerolGluconeogenesisAutophagyConcentrations of glucoseNoradrenergic systemFatty acidsGlucose productionGlycerolStable isotopesAtg7MetabolismGlucoseTurnoverCaMKII1790-P: TLC-1180 Enhances Liver, Muscle, WAT, and Myocardial Insulin Sensitivity and Increases Exercise Capacity in DIO Mice
PARIKH S, SHARMA M, GASPAR R, HUANG X, ZHANG D, DUFOUR S, MORGAN H, NASIRI A, ZHENG J, KAHN M, STACK J, MYERS R, SUBRAMANIAN G, VIJAYAKUMAR A, SHULMAN G. 1790-P: TLC-1180 Enhances Liver, Muscle, WAT, and Myocardial Insulin Sensitivity and Increases Exercise Capacity in DIO Mice. Diabetes 2026, 75 DOI: 10.2337/db26-1790-p.Peer-Reviewed Original ResearchHyperinsulinemic-euglycemic clampWhite adipose tissueInsulin resistanceExercise capacityDIO miceGraded exercise testMaximal running speedInsulin sensitivityIncreased exercise capacityPreserved Ejection FractionSuppression of endogenous glucose productionWhole-body insulin sensitivityMyocardial insulin sensitivityInsulin-stimulated 2-DG uptakeVisceral white adipose tissueExercise performanceCardiac fitnessWhole-body insulin resistanceExercise testPathogenesis of T2DExercise durationEjection fractionPreclinical findingsLean controlsCardiac functionInsulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol
Hubbard B, Ma Y, Gaspar R, LaMoia T, Zhang D, Kahn M, Dufour S, Nasiri A, Shulman G. Insulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol. Nature Communications 2026 PMID: 42168167, DOI: 10.1038/s41467-026-73016-0.Peer-Reviewed Original ResearchHigh-fat dietRenal glucose productionSn-1,2-DAGElevated 6.5-foldImpaired suppression of endogenous glucose productionGlucose productionDysregulated glucose homeostasisMitochondrial metabolismInsulin signalingMitochondrial sourcesInsulin resistanceHigh-fat diet micePyruvate oxidationHFD-fedGlucose homeostasisKnockin miceGluconeogenesisPhosphorylationEndogenous glucose productionRenal gluconeogenesisGlycerolMiceImpaired suppressionMale micePyruvateEvolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains
Morini M, Bergqvist C, Asturiano J, Dufour S, Larhammar D. Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains. Molecular Biology And Evolution 2026, 43: msag098. PMID: 41968578, PMCID: PMC13143021, DOI: 10.1093/molbev/msag098.Peer-Reviewed Original ResearchConceptsGene duplicationHomology domainComplex gene familyLoss of genesADP-ribose pyrophosphataseOrigin of bilateriansAncestor geneAnimal lineagesGene lossEarly chordatesGnathostome ancestorVertebrate ancestorGene familyDomain gainsEvolutionary variationKinase domainAncestorGenesMetazoansGnathostomesDuplicationOhnologsBilateriansIntronDistinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD
Qadri S, Porthan K, Dufour S, Lehtimäki T, Petersen K, Shulman G, Yki-Järvinen H, Luukkonen P. Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD. Journal Of Hepatology 2026, 85: 26-36. PMID: 41655910, DOI: 10.1016/j.jhep.2026.02.001.Peer-Reviewed Original ResearchNon-ketogenic dietIntrahepatic triglyceride contentKetogenic dietIntrahepatic triglycerideSteatosis resolutionLiver injuryPlasma concentrationsLiver diseaseSteatotic liver diseaseAbstractText Label="Background &Susceptible to liver injuryProton magnetic resonance spectroscopyLiver fat reductionProgressive liver injuryWeight lossOptimal dietary approachWeight-loss dietsConcentrations of branched-chain amino acidsBody fat lossBenefits of KDPlasma concentrations of branched-chain amino acidsSystemic metabolic responseBranched-chain amino acidsAbstractText Label="ImpactMitochondrial tricarboxylic acid
2025
Evolutionary adaptation of anaerobic and aerobic metabolism to high sulfide and hypoxic hydrothermal vent crab, Xenograpsus testudinatus
Chen C, Wu G, Tseng Y, Dufour S, Chang C. Evolutionary adaptation of anaerobic and aerobic metabolism to high sulfide and hypoxic hydrothermal vent crab, Xenograpsus testudinatus. Scientific Reports 2025, 16: 2123. PMID: 41392055, PMCID: PMC12808302, DOI: 10.1038/s41598-025-31968-1.Peer-Reviewed Original ResearchConceptsVent habitatsEnzymatic activityLong-term exposureVent crabsSulfide toleranceHydrothermal vent crabsHydrothermal vent habitatsAerobic metabolismIncrease of transcriptionHydrothermal vent environmentsAnaerobic metabolismHemolymph lactate levelsPhylogenetic analysisMitochondrial respiratory functionIntertidal speciesCapture siteEvolutionary adaptationSulfide detoxificationProducts of anaerobic metabolismAerobic respirationParalogsVent environmentsQuinone oxidoreductaseSulfide toxicityMetabolic adaptationCorrection: Microbial diversity and pigment synthesis in the accessory nidamental gland: species-specific and color-associated patterns in bigfin reef squid (Sepioteuthis lessoniana)
Chiu L, Guo J, Li H, Chang H, Yang S, Dufour S, Chang C, Tseng Y, Wu G. Correction: Microbial diversity and pigment synthesis in the accessory nidamental gland: species-specific and color-associated patterns in bigfin reef squid (Sepioteuthis lessoniana). Animal Microbiome 2025, 7: 109. PMID: 41107996, PMCID: PMC12535005, DOI: 10.1186/s42523-025-00481-1.Commentaries, Editorials and LettersIn vitro and in silico insights on the regulation by gonadal hormones of pituitary GnRH receptor expression in a basal teleost, the European eel
Lin C, Rousseau K, Chang C, Dufour S. In vitro and in silico insights on the regulation by gonadal hormones of pituitary GnRH receptor expression in a basal teleost, the European eel. Frontiers In Endocrinology 2025, 16: 1673260. PMID: 41089285, PMCID: PMC12515627, DOI: 10.3389/fendo.2025.1673260.Peer-Reviewed Original ResearchConceptsTranscription Factor Binding SitesFactor binding sitesBasal teleostsGonadal hormonesLuteinizing hormoneRegulatory mechanismsDeficient productionPrimary culturesResponse to gonadotropin-releasing hormoneBinding sitesGnRH receptor expressionPituitary sensitivity to GnRHEffects of steroidsUnique life cycleNon-aromatizable androgensSexual maturityIn silico insightSensitivity to GnRHGonadotropin-releasing hormonePrimary cultures of eel pituitary cellsOvulatory luteinizing hormoneEvolutionary conservationEffects of testosteroneReceptor expressionEel pituitary cellsLes métamorphoses chez les poissons et leurs régulations endocriniennes
Dufour S, Sachs L, Martin P, Rousseau K. Les métamorphoses chez les poissons et leurs régulations endocriniennes. Biologie Aujourd Hui 2025, 219: 37-50. PMID: 40694674, DOI: 10.1051/jbio/2025002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSecondary metamorphosisLarval metamorphosisEvolution of complex life cyclesEvolution of vertebratesControl of metabolismComplex life cycleControl of thyroid hormonesDiverse habitatsNeuroendocrine controlAnimal kingdomAmphibiansVertebrate metamorphosisMetamorphosis of amphibiansControl of metamorphosisGrowth phaseVertebratesJuvenile stageTeleostReproductive phaseMigratory fishHabitatMetamorphosisCyclostomesLarvalSalmon smoltificationRobustness of gametogenesis in the scleractinian coral, Tubastraea aurea, in the shallow-water hydrothermal vent field off Kueishan Island, northeastern Taiwan
Corrigan E, Chen C, Wang B, Dufour S, Chang C. Robustness of gametogenesis in the scleractinian coral, Tubastraea aurea, in the shallow-water hydrothermal vent field off Kueishan Island, northeastern Taiwan. The Science Of The Total Environment 2025, 992: 179901. PMID: 40561834, DOI: 10.1016/j.scitotenv.2025.179901.Peer-Reviewed Original ResearchConceptsScleractinian coralsReproductive resilienceHydrothermal ventsSexual reproductionT. aureaSeasonal timingCoral reef ecosystemsKueishan IslandSeasonal variationNortheastern TaiwanSexual reproductive strategiesEvolutionary time framesTiming of reproductionReef ecosystemsSeasonal timing of reproductionPresence of larvaeSea surface temperatureUnique ecosystemsOcean acidificationSeasonal variation of water temperatureHydrothermal vent fieldsVariation of water temperatureAcidified conditionsGametogenetic processesLarval production