fMRI, Neural Patterns & the Etiology of Irritability - the YAY Lab at Yale School Of Medicine

Transcript

• 00:05We see chronic irritability
• 00:07affect
• 00:08many aspects of the kid's
• 00:10life.
• 00:11And we have also seen
• 00:12that, irritability
• 00:14seem to be among the
• 00:15top reason
• 00:16for why kids were referred
• 00:18to the clinic and mental
• 00:19health services.
• 00:21And research has also shown
• 00:23that
• 00:24irritability
• 00:25in early childhood
• 00:26seemed to be a robust
• 00:27predictor for later negative outcomes.
• 00:30So this include anxiety, depression,
• 00:33suicidality.
• 00:38My research focuses on, irritability,
• 00:41anger, and aggression in children
• 00:43and adolescents.
• 00:44So these are the kids
• 00:45who
• 00:46have low frustration tolerance.
• 00:48Any little things can easily
• 00:50set them off, and they
• 00:51often have frequent,
• 00:53severe
• 00:54dysregulated
• 00:55temporal bursts.
• 01:00In our lab, fMRI is
• 01:02one of the main component
• 01:04in the sense that we
• 01:05wanted to better understand,
• 01:07what goes on in kids
• 01:09with irritability
• 01:11sprain.
• 01:11So we have them
• 01:13come into the lab, and
• 01:15then we put them inside
• 01:16the MRI scanner.
• 01:18And we have them play
• 01:19some games
• 01:20that are designed to frustrate
• 01:21them so that we can
• 01:23see
• 01:24how their brain respond and
• 01:26what are the different
• 01:28areas that are activated
• 01:30and how do the different
• 01:31brain region communicate, talk to
• 01:33each others
• 01:34while kids are experiencing
• 01:36frustration
• 01:37and trying to regulate frustration
• 01:39inside the scanner in real
• 01:41time.
• 01:42In the new studies that
• 01:43we are launching,
• 01:45we invite the parent and
• 01:47the child to our lab
• 01:49and have them do some
• 01:50sort of interaction task,
• 01:52and we wanted to see
• 01:54how the child's frustration
• 01:56manifest
• 01:57in their physiology.
• 02:02Given the severity and the
• 02:04impairment that these kids experience,
• 02:07surprisingly, there's very little treatment
• 02:09options for them, especially treatment
• 02:12that's specifically designed to target
• 02:14irritability.
• 02:16So with the fMRI study,
• 02:18what we're hoping to do
• 02:19is to identify some
• 02:21neuro signatures,
• 02:22so neural markers.
• 02:24So this could be, how
• 02:26the different brain regions
• 02:28activate
• 02:28or how they communicate with
• 02:30each other
• 02:31and take these neural markers
• 02:34and then treat them like
• 02:35a target.
• 02:36And so if we can
• 02:38move those neural targets targets
• 02:40using some sort of,
• 02:42therapeutics,
• 02:43this could be behavioral therapy,
• 02:45psychotherapy,
• 02:46or,
• 02:48pharmacological
• 02:49therapy, we might be able
• 02:50to see the downstream changes
• 02:52in terms of reduction in
• 02:54irritability
• 02:54symptoms.