Nenad Sestan, MD, PhD
Harvey and Kate Cushing Professor of Neuroscience, and Professor of Comparative Medicine, of Genetics and of PsychiatryCards
About
Research
Publications
2026
Targeted Biospecimen Collection to Meet High Priority Pediatric Health Needs: The Developmental Genotype-Tissue Expression Project
Van Hoose PM, Linn RL, VonDran MW, Taylor D, Blanchard TG, Hernandez RG, Faith MA, Pryhuber GS, Huyck HL, LeFevre AN, Johnson R, Roberts VH, Lewis AD, Anderson L, Kovner R, Pfeiffer M, McGillcuddy M, Grimm M, Czaplicki J, Heinemann C, Salehi A, Sanagavarapu B, Suplee L, Ryan C, DiMarino N, Nissley N, Clarke J, Chard A, Gilbert M, Savannah E, Kreeb J, Roberts R, Corbit VL, Ardlie K, Sestan N, Bell TJ, . Targeted Biospecimen Collection to Meet High Priority Pediatric Health Needs: The Developmental Genotype-Tissue Expression Project. Biopreservation And Biobanking 2026, 19475535261468926. DOI: 10.1177/19475535261468926.Peer-Reviewed Original ResearchCompeting programs shape cortical sensorimotor–association axis development
Tsyporin J, Zhang M, Qi C, Segal A, Li X, Kim H, Choi SH, Pavlovic I, Bandiera S, Finn T, Kim SK, Shibata A, Nakamura T, Onishi K, Zhang Z, Hammarlund E, Su G, Salla N, Kachko J, Hawley C, Li S, Doyle DZ, Peng X, Nottoli T, Ruiz-Reig N, Tissir F, Nakagawa Y, Herzog E, Ma S, Gobeske K, Pattabiraman K, Shimogori T, Duque A, Fornito A, Huang H, Shibata M, Chen B, Sestan N. Competing programs shape cortical sensorimotor–association axis development. Nature 2026, 656 DOI: 10.1038/s41586-026-10699-x.Peer-Reviewed Original ResearchGenomic sequence evolution underlying human neocortical interareal diversification
He W, Hou W, Jiang C, Zhang X, Wang Y, Zhou Y, Gobeske KT, Ma S, Fan J, Wang H, Li P, Xie W, Yan B, Sestan N, Chen L, Zhang J, Zhu Y. Genomic sequence evolution underlying human neocortical interareal diversification. Genome Biology 2026, 27: 269. DOI: 10.1186/s13059-026-04177-w.Peer-Reviewed Original ResearchNeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development
Sonthalia S, Herb B, Adkins R, Orvis J, Li G, Liao X, Yu Q, Blanco X, Casella A, Liu J, Stein-O’Brien G, Caffo B, Hertzano R, Mahurkar A, Xu J, Gillis J, Werner J, Ma S, Kim S, Micali N, Sestan N, Rakic P, Santpere G, Ament S, Colantuoni C. NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development. Nature Neuroscience 2026, 29: 978-991. PMID: 41882195, PMCID: PMC13061640, DOI: 10.1038/s41593-026-02204-4.Peer-Reviewed Original ResearchAdaptive evolution of gene regulatory networks in mammalian neocortex
Li Z, Kaur N, Santpere G, Muchnik S, Sindhu S, Qi C, Shibata M, Clément O, Klarić T, de Martin X, Luria V, Cho H, Li M, Shibata A, Choi S, Kim H, Tebbenkamp A, Ma S, Han W, Kim S, Pochareddy S, Duy P, Xing X, Bao Y, Xu X, Gladwyn-Ng I, Cullen H, Paolino A, Fenlon L, Kozulin P, Suárez R, Risgaard R, Gulden F, Karger A, Suzuki I, Hirata T, Gobeske K, Richards L, Sousa A, Heng J, Sestan N. Adaptive evolution of gene regulatory networks in mammalian neocortex. Nature 2026, 653: 156-166. PMID: 41851468, PMCID: PMC13149332, DOI: 10.1038/s41586-026-10226-y.Peer-Reviewed Original ResearchHuman-specific features of the cerebellum and ZP2-regulated synapse development
Kim S, Cherskov A, Sindhwani A, Choi S, Kim H, Li M, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young D, Estacion M, Zhang Y, Ruiz-Jiménez J, Nadkarni A, Luria V, Sindhu S, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen R, Risgaard R, Li X, Pochareddy S, Karger A, Huttner A, Morozov Y, Daadi E, Colantuoni C, Gobeske K, Ely J, Hof P, Daadi M, Sherwood C, Duque A, Ma S, Sousa A, Waxman S, Rakic P, Santpere G, Sanders S, Sestan N. Human-specific features of the cerebellum and ZP2-regulated synapse development. Cell 2026, 189: 1802-1819.e28. PMID: 41819103, DOI: 10.1016/j.cell.2026.02.014.Peer-Reviewed Original ResearchEndovascular thrombectomy for acute stroke: evolving eligibility criteria and adjunct therapies
Glavan M, Liu J, Sampaio Silva G, Nguyen T, Zhou J, Sestan N, Kimberly W, Sheth K. Endovascular thrombectomy for acute stroke: evolving eligibility criteria and adjunct therapies. The Lancet Neurology 2026, 25: 61-76. PMID: 41389830, DOI: 10.1016/s1474-4422(25)00356-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness
Roussos P, Vaccarino F, Weng Z, Sestan N, Gerstein M, Geschwind D. PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness. Neuron 2025, 113: 4099-4102. PMID: 41412064, DOI: 10.1016/j.neuron.2025.11.027.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSpatial dynamics of brain development and neuroinflammation
Zhang D, Rubio Rodríguez-Kirby L, Lin Y, Wang W, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Bao S, Wang S, Chen X, Gao F, Wang D, Xu H, Ma C, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. Spatial dynamics of brain development and neuroinflammation. Nature 2025, 647: 213-227. PMID: 41193846, PMCID: PMC12589135, DOI: 10.1038/s41586-025-09663-y.Peer-Reviewed Original ResearchThe new frontier in understanding human and mammalian brain development
Nowakowski T, Nano P, Matho K, Chen X, Corrigan E, Ding W, Gao Y, Heffel M, Jayakumar J, Kaplan H, Kronman F, Kovner R, Mannens C, Song M, Steyert M, Venkatesan S, Wallace J, Wang L, Werner J, Zhang D, Yuan G, Zuo G, Ament S, Colantuoni C, Dulac C, Fan R, Gillis J, Kriegstein A, Krienen F, Kim Y, Linnarsson S, Mitra P, Pollen A, Sestan N, Tward D, van Velthoven C, Yao Z, Bhaduri A, Zeng H. The new frontier in understanding human and mammalian brain development. Nature 2025, 647: 51-59. PMID: 41193845, PMCID: PMC13108688, DOI: 10.1038/s41586-025-09652-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Academic Achievements & Community Involvement
News & Links
News
- August 31, 2026
Yale School of Medicine Awarded a Nearly $25 Million Grant to Map the Developing Brain and Advance Autism Research
- October 23, 2025
2025 Yale-KU Forum: Clinical and Basic Neuroscience
- July 10, 2024
Highlighting Yale’s Neuroscience Research
- July 03, 2024
Bandler Honored with 2024 National Institute of Mental Health Outstanding Resident Award
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Neuroscience
PO Box 208001, 333 Cedar Street
New Haven, CT 06520-8001
United States