Hattie Chung
Cards
About
Research
Publications
2024
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Tamura T, Cheng C, Villaseñor-Altamirano A, Yamada K, Ikeda K, Hayashida K, Menon J, Chen X, Chung H, Varon J, Chen J, Choi J, Cullen A, Guo J, Lin X, Olenchock B, Pinilla-Vera M, Manandhar R, Sheikh M, Hou P, Lawler P, Oldham W, Seethala R, Baron R, Bohula E, Morrow D, Blumberg R, Chen F, Merriam L, Weissman A, Brenner M, Chen X, Ichinose F, Kim E, Sohn H, Rolland T, Weil B. Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation. Science Translational Medicine 2024, 16: eadq5796. PMID: 39630883, PMCID: PMC11792709, DOI: 10.1126/scitranslmed.adq5796.Peer-Reviewed Original ResearchConceptsOut-of-hospital cardiac arrestCohort of patientsNeurological outcomeT cellsImmune cellsCardiac arrestNatural killer (NK) cellsAssociated with good neurological outcomesDiverse T cell receptor repertoireNeurological injuryT cell receptor repertoireAssociated with poor neurological outcomeIncreased inflammatory chemokineInnate T cellsPoor neurological outcomeWild-type micePost-cardiac arrestAccumulation of macrophagesIncreased neuronal injuryBrains of miceNKT cellsTreated miceReceptor repertoireInflammatory chemokinesCytokine expression
2022
Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections
Chung H, Merakou C, Schaefers M, Flett K, Martini S, Lu R, Blumenthal J, Webster S, Cross A, Al Ahmar R, Halpin E, Anderson M, Moore N, Snesrud E, Yu H, Goldberg J, O’Toole G, McGann P, Stam J, Hinkle M, McAdam A, Kishony R, Priebe G. Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections. Nature Communications 2022, 13: 1231. PMID: 35264582, PMCID: PMC8907320, DOI: 10.1038/s41467-022-28188-w.Peer-Reviewed Original ResearchConceptsAntibiotic resistance mutationsResistance mutationsLong-read sequencingEvolution of antibiotic resistanceSputum samplesRespiratory infectionsCulture-based methodsLow-frequency resistance mutationsColonization bottlenecksEarly stages of infectionDays of therapyAcute bacterial infectionBacterial respiratory infectionsMechanically ventilated patientsGenomic surveillanceResistance phenotypeStages of infectionAntibiotic resistanceIn vivo frequencyAntibiotic therapyAntibiotic changeMutationsAntibiotic switchTherapy choiceIndividual patients
2021
Joint single-cell measurements of nuclear proteins and RNA in vivo
Chung H, Parkhurst C, Magee E, Phillips D, Habibi E, Chen F, Yeung B, Waldman J, Artis D, Regev A. Joint single-cell measurements of nuclear proteins and RNA in vivo. Nature Methods 2021, 18: 1204-1212. PMID: 34608310, PMCID: PMC8532076, DOI: 10.1038/s41592-021-01278-1.Peer-Reviewed Original ResearchConceptsGene expressionNuclear proteinsAnalysis of transcription factor (TFTranscription factor (TFGenome-wide associationRNA in vivoQuantitate protein levelsNative tissue contextModel gene expressionGene expression in vivoGene networksExpression in vivoInduction of neuronal activityGene targetingClinical specimensTissue contextGenesTranscriptomeProtein levelsProteinMouse brainExpressionCellular indicesPharmacological inductionTF
2019
The microbiota regulate neuronal function and fear extinction learning
Chu C, Murdock M, Jing D, Won T, Chung H, Kressel A, Tsaava T, Addorisio M, Putzel G, Zhou L, Bessman N, Yang R, Moriyama S, Parkhurst C, Li A, Meyer H, Teng F, Chavan S, Tracey K, Regev A, Schroeder F, Lee F, Liston C, Artis D. The microbiota regulate neuronal function and fear extinction learning. Nature 2019, 574: 543-548. PMID: 31645720, PMCID: PMC6818753, DOI: 10.1038/s41586-019-1644-y.Peer-Reviewed Original ResearchAnimalsAnti-Bacterial AgentsAutistic DisorderBloodCalciumCerebrospinal FluidCuesDendritic SpinesExtinction, PsychologicalFearFecesGerm-Free LifeIndicanMaleMetabolomicsMiceMice, Inbred BALB CMice, Inbred C57BLMicrobiotaNeural InhibitionNeurogliaNeuronsPhenylpropionatesPrefrontal CortexSchizophreniaTranscriptomeVagus Nerve
2017
Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung
Chung H, Lieberman T, Vargas S, Flett K, McAdam A, Priebe G, Kishony R. Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung. Nature Communications 2017, 8: 14078. PMID: 28102223, PMCID: PMC5253648, DOI: 10.1038/ncomms14078.Peer-Reviewed Original Research
2016
RNA Structural Determinants of Optimal Codons Revealed by MAGE-Seq
Kelsic E, Chung H, Cohen N, Park J, Wang H, Kishony R. RNA Structural Determinants of Optimal Codons Revealed by MAGE-Seq. Cell Systems 2016, 3: 563-571.e6. PMID: 28009265, PMCID: PMC5234859, DOI: 10.1016/j.cels.2016.11.004.Peer-Reviewed Original Research
2015
Isocost Lines Describe the Cellular Economy of Genetic Circuits
Gyorgy A, Jiménez J, Yazbek J, Huang H, Chung H, Weiss R, Del Vecchio D. Isocost Lines Describe the Cellular Economy of Genetic Circuits. Biophysical Journal 2015, 109: 639-646. PMID: 26244745, PMCID: PMC4572570, DOI: 10.1016/j.bpj.2015.06.034.Peer-Reviewed Original ResearchInexpensive Multiplexed Library Preparation for Megabase-Sized Genomes
Baym M, Kryazhimskiy S, Lieberman T, Chung H, Desai M, Kishony R. Inexpensive Multiplexed Library Preparation for Megabase-Sized Genomes. PLOS ONE 2015, 10: e0128036. PMID: 26000737, PMCID: PMC4441430, DOI: 10.1371/journal.pone.0128036.Peer-Reviewed Original Research
2012
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery
Nguyen D, Mahon K, Chikh G, Kim P, Chung H, Vicari A, Love K, Goldberg M, Chen S, Krieg A, Chen J, Langer R, Anderson D. Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e797-e803. PMID: 22421433, PMCID: PMC3325698, DOI: 10.1073/pnas.1121423109.Peer-Reviewed Original Research
Teaching & Mentoring
Teaching
Didactic MCDB 370: Biotechnology
LecturerLecture Setting02/01/2024 - PresentForUndergraduate6 Average Instructional Hours Per YearThe principles and applications of cellular, molecular, and chemical techniques that advance biotechnology. The most recent tools and strategies used by industrial labs, academic research, and government agencies to adapt biological and chemical compounds as medical treatments, as industrial agents, or for the further study of biological systems.
News
News
- April 17, 2025Source: Google Research
Teaching machines the language of biology: Scaling large language models for next-generation single-cell analysis
- February 07, 2024
Welcome New Staff, Faculty, Postdocs & Postgrads (February 2024)
- January 09, 2024
Recap & Reflections: Vascular Biology & Therapeutics Program & Cardiovascular Research Center 2023 Retreat
- October 10, 2022Source: Nature Methods
The joy of transcending disciplines
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Locations
300 George Street
Lab
New Haven, CT 06511
Events
Oct 202513Monday
Everyone Chen Liu, MD, PhD - Anthony Koleske, PhD - Vishwa Deep Dixit, DVM, PhD - Ruth R Montgomery, PhD - Rong Fan, PhD - Albert C Shaw, MD, PhD - Hattie Chung - Hee-Hoon Kim, PhD - Venki Ramakrishnan, PhD - Laura Niedernhofer, MD, PhD - Miriam Merad, MD, PhD - Berenice Benayoun, PhD - Jarrod Dudakov, PhD - Navadeep Chandel, PhD - Vadim Gladyshev, PhD