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Experimental drug that targets liver fat may help prevent diabetes

An experimental drug has reversed the build-up of fat in the liver and lowered blood levels of fatty substances including cholesterol in non-human primates. The build-up of fat in the liver, known as non-alcoholic fatty liver disease, affects 1 in 3 people and can lead to type 2 diabetes as well as heart and kidney disease.

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  • You have two ages, chronological and biological. Here's why it matters

    Essentially, everyone has two ages: a chronological age, how old the calendar says you are, and a phenotypic or biological age, basically the age at which your body functions as it compares to average fitness or health levels. Levine and her team identified nine biomarkers taken in a simple blood test that seemed to be the most influential on lifespan. The biomarkers include blood sugar, kidney and liver measures, and immune and inflammatory measures. Levine plugs those numbers into the computer, and the algorithm does the rest. People with a biological age lower than their chronological age have a lower mortality risk, while those aging older from a biological standpoint have a higher mortality risk and are potentially more prone to developing the diseases associated with the higher age range.

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  • Yale center dedicated to research on older adults receives renewed funding

    For the fifth consecutive time, the Yale Claude D. Pepper Older Americans Independence Center (OAIC) has been renewed for funding from the National Institute on Aging (NIA). The Center is one of only two such programs nationwide to receive continuous NIA support since it was first funded in 1992, marking more than 25 years of excellence in geriatrics and aging research under the leadership of Geriatrics Section Chief Dr. Mary Tinetti, Dr. Thomas Gill, and Dr. Terri Fried.

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Yale Center for
Research on Aging (Y-Age)

Yale School of Medicine 
Department of Pathology 
PO Box 208023  
New Haven, CT 06520