1987
Biological versus mechanical valves Analysis of 1,116 valves inserted in 1,012 adult patients with a 4,818 patient-year and a 5,327 valve-year follow-up
Hammond G, Geha A, Kopf G, Hashim S. Biological versus mechanical valves Analysis of 1,116 valves inserted in 1,012 adult patients with a 4,818 patient-year and a 5,327 valve-year follow-up. Journal Of Thoracic And Cardiovascular Surgery 1987, 93: 182-198. PMID: 3807394, DOI: 10.1016/s0022-5223(19)36440-2.Peer-Reviewed Original ResearchConceptsBiological valvesMechanical valvesPerivalvular leakValve failureMechanical prosthetic heart valvesYale-New Haven HospitalAnticoagulation-related hemorrhageLate cardiac deathValve-related mortalityValve-related deathIncidence of thromboembolismType of valveYears of ageProsthetic heart valvesAdult patientsTotal morbidityCardiac deathPatientsHeart valvesReoperationThromboembolismSignificant differencesValve analysisLittle direct evidenceYear period
1986
Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics.
Rothstein P, Arthur G, Feldman H, Kopf G, Covino B. Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics. Anesthesia & Analgesia 1986, 65: 625. PMID: 3706800, DOI: 10.1213/00000539-198606000-00011.Peer-Reviewed Original ResearchConceptsIntercostal nerve blockNerve blockBupivacaine concentrationsX minTotal body clearanceVolume of distributionPlasma concentration ratioSteady-state volumeBlood concentration valuesAdult patientsBody clearancePlasma concentrationsBlood concentrationsLocal anestheticsPharmacokinetic evaluationIntercostal spaceBupivacaine HClPharmacokinetic parametersApparent volumeAdditional groupHematocritBupivacaineChildrenClearanceAdults