Featured Publications
Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients
Qu R, Gupta K, Dong D, Jiang Y, Landa B, Saez C, Strickland G, Levinsohn J, Weng PL, Taketo MM, Kluger Y, Myung P. Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients. Developmental Cell 2022, 57: 1053-1067.e5. PMID: 35421372, PMCID: PMC9050909, DOI: 10.1016/j.devcel.2022.03.011.Peer-Reviewed Original ResearchConceptsMorphogen gradientsCell fate specificationWnt/β-cateninFate specificationShape tissuesOrgan formationCell fateDermal condensatesGenetic perturbationsNiche formationDifferentiation processSpatiotemporal patterningCell behaviorΒ-cateninMore intermediatesComputational approachProliferationMorphogenesisScRNAOrganogenesisShhKey componentProgenitorsCritical transitionDKK1Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis
Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P. Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis. Developmental Cell 2018, 48: 17-31.e6. PMID: 30595533, PMCID: PMC6361530, DOI: 10.1016/j.devcel.2018.11.032.Peer-Reviewed Original ResearchConceptsDermal condensatesSingle-cell RNA sequencingUnbiased single-cell RNA sequencingWnt/β-catenin signalingΒ-catenin signalingTranscriptional statesDifferentiation trajectoriesAppendage morphogenesisRNA sequencingHF morphogenesisCellular eventsRecent progenyCell differentiationMorphogenesisClusters of cellsMolecular differencesDistinctive populationCell analysisCellsDifferentiationHF developmentProgenySignalingDC cellsSequencingThe development of hair follicles and nail
Lee S, Platt S, Lim C, Ito M, Myung P. The development of hair follicles and nail. Developmental Biology 2024, 513: 3-11. PMID: 38759942, DOI: 10.1016/j.ydbio.2024.05.010.Peer-Reviewed Original ResearchGene trajectory inference for single-cell data by optimal transport metrics
Qu R, Cheng X, Sefik E, Stanley III J, Landa B, Strino F, Platt S, Garritano J, Odell I, Coifman R, Flavell R, Myung P, Kluger Y. Gene trajectory inference for single-cell data by optimal transport metrics. Nature Biotechnology 2024, 1-11. PMID: 38580861, PMCID: PMC11452571, DOI: 10.1038/s41587-024-02186-3.Peer-Reviewed Original ResearchGene dynamicsGene programTrajectory inferenceBiological processesCell-cell graphDynamics of genesCell trajectory inferenceSingle-cell RNA sequencingSingle-cell dataCell state transitionsMyeloid lineage maturationDynamics of biological processesGene distributionRNA sequencingPseudotemporal orderingGene processingTrajectories of cellsGenesActivity of biological processesTechnical noiseGroups of cellsLineage maturationCellsConstruct cellsSequenceThe origins of skin diversity: lessons from dermal fibroblasts
Myung P, Andl T, Atit R. The origins of skin diversity: lessons from dermal fibroblasts. Development 2022, 149 PMID: 36444877, PMCID: PMC10112899, DOI: 10.1242/dev.200298.Peer-Reviewed Original ResearchConceptsFibroblast subtypesSingle-cell levelWnt/β-cateninLineage diversificationHair follicle growthDermal developmentDermal fibroblastsExtraordinary diversityPositional signalsNatural variationFibroblast heterogeneityΒ-cateninDevelopmental originsDiverse groupMolecular heterogeneityCentral roleDiversityFibroblastsFollicle growthImportant roleLineagesSpeciesDiversificationDifferentiationOrigin
2024
676 Wnt and SHH interact to determine hair follicle dermal condensate fate
Jiang Y, Myung P. 676 Wnt and SHH interact to determine hair follicle dermal condensate fate. Journal Of Investigative Dermatology 2024, 144: s118. DOI: 10.1016/j.jid.2024.06.692.Peer-Reviewed Original ResearchCognitive Bias in the Patient Encounter: Part II. Debiasing using an adaptive toolbox
Ko C, Gehlhausen J, Cohen J, Jiang Y, Myung P, Croskerry P. Cognitive Bias in the Patient Encounter: Part II. Debiasing using an adaptive toolbox. Journal Of The American Academy Of Dermatology 2024 PMID: 38588820, DOI: 10.1016/j.jaad.2024.02.061.Peer-Reviewed Original ResearchRapidly progressive subungual gray-brown melanonychia
Echeandia-Francis C, Nock M, Myung P, Zubek A. Rapidly progressive subungual gray-brown melanonychia. JAAD Case Reports 2024, 44: 113-115. PMID: 38414828, PMCID: PMC10897537, DOI: 10.1016/j.jdcr.2024.01.013.Peer-Reviewed Original Research
2023
Solving a molecular cryptogram for the human fingerprint
Myung P, Ito M. Solving a molecular cryptogram for the human fingerprint. Cell 2023, 186: 899-901. PMID: 36868211, DOI: 10.1016/j.cell.2023.01.032.Peer-Reviewed Original Research
2022
Segmental basaloid follicular hamartomas derive from a post‐zygotic SMO p.L412F pathogenic variant and express hair follicle development‐related proteins in a pattern that distinguish them from basal cell carcinomas
Atzmony L, Ugwu N, Bercovitch LG, Robinson‐Bostom L, Ko CJ, Myung P, Choate KA. Segmental basaloid follicular hamartomas derive from a post‐zygotic SMO p.L412F pathogenic variant and express hair follicle development‐related proteins in a pattern that distinguish them from basal cell carcinomas. American Journal Of Medical Genetics Part A 2022, 188: 3525-3530. PMID: 35972041, PMCID: PMC9669121, DOI: 10.1002/ajmg.a.62951.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaCell carcinomaFollicular hamartomaProliferation indexBasaloid skin tumorsSporadic basal cell carcinomasBasaloid follicular hamartomaKi-67 expressionLow proliferation indexCentral nervous systemWhole-exome sequencingSystemic involvementExpression of hedgehogMultiple lesionsSkin tumorsWnt/beta-catenin pathwayBasaloid lesionsNervous systemVariable involvementPathogenic variantsSegmental distributionPost-zygotic mutational eventSOX-9 expressionNormal tissuesExome sequencingWound Healing Induced Hair Follicle Regeneration
Jiang Y, Myung P. Wound Healing Induced Hair Follicle Regeneration. Stem Cell Biology And Regenerative Medicine 2022, 72: 277-290. DOI: 10.1007/978-3-030-98331-4_13.Peer-Reviewed Original ResearchEmbryonic hair follicle developmentHair follicle developmentHair follicle regenerationHair follicle neogenesisDe novo hair folliclesComplex cellular signalingFollicle regenerationFollicle neogenesisDifferent cellular behaviorsHair follicle formationFollicle developmentLimited regeneration potentialCellular signalingExtrinsic signalsAppendage formationMore mechanistic studiesHair neogenesisCellular behaviorRegenerative woundCrucial playersHair folliclesAdult mammalsRegeneration potentialFollicle formationMammals
2021
Inference and analysis of cell-cell communication using CellChat
Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, Myung P, Plikus MV, Nie Q. Inference and analysis of cell-cell communication using CellChat. Nature Communications 2021, 12: 1088. PMID: 33597522, PMCID: PMC7889871, DOI: 10.1038/s41467-021-21246-9.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencing dataCell-cell communicationEffective systems-level analysesDatabase of interactionsRNA sequencing dataIntercellular communication networksContext-specific pathwaysCellChatDiverse tissuesIntercellular communicationSystem-level analysisSignaling linkNetwork analysisPathwayCellsMolecular complexesCofactorComplexesReceptors
2020
Cutaneous Vasculitis After Ustekinumab Induction in Crohn’s Disease
Chugh R, Proctor DD, Little A, Myung P, Cowper S, Imaeda S, Pashankar DS, Al-Bawardy B. Cutaneous Vasculitis After Ustekinumab Induction in Crohn’s Disease. Inflammatory Bowel Diseases 2020, 27: e30-e31. PMID: 33179735, DOI: 10.1093/ibd/izaa285.Peer-Reviewed Case Reports and Technical NotesPink plaques on the face of an adolescent male
Gehlhausen JR, Myung P, Zubek A. Pink plaques on the face of an adolescent male. International Journal Of Dermatology 2020, 60: e217-e218. PMID: 33084046, DOI: 10.1111/ijd.15265.Peer-Reviewed Original ResearchCutaneous Involvement in Plasma Cell Myeloma
Panse G, Subtil A, McNiff JM, Glusac EJ, Ko CJ, Galan A, Myung P, Xu ML. Cutaneous Involvement in Plasma Cell Myeloma. American Journal Of Clinical Pathology 2020, 155: 106-116. PMID: 32885235, DOI: 10.1093/ajcp/aqaa122.Peer-Reviewed Original ResearchConceptsPlasma cell myelomaCutaneous involvementSquamous cell carcinomaAmyloid depositionCell carcinomaCell myelomaCases of PCMBone marrow involvementCyclin D1 immunoreactivityDisease-related deathLight chain restrictionCCND1 gene rearrangementMarrow involvementSkin involvementClinicopathologic featuresCytomorphologic spectrumCutaneous lesionsPoor outcomeCommon immunophenotypeChain restrictionClinical dataCytogenetic findingsOlder individualsGene rearrangementsMyelomaTender subcubcutaneous plaques in a patient with acute myeloid leukemia
Olamiju B, Myung P, Grant M, Leventhal JS. Tender subcubcutaneous plaques in a patient with acute myeloid leukemia. International Journal Of Dermatology 2020, 60: 311-313. PMID: 32424815, DOI: 10.1111/ijd.14943.Peer-Reviewed Case Reports and Technical Notes
2019
Ixekizumab-induced alopecia areata
Eldirany SA, Myung P, Bunick CG. Ixekizumab-induced alopecia areata. JAAD Case Reports 2019, 6: 51-53. PMID: 31909139, PMCID: PMC6938813, DOI: 10.1016/j.jdcr.2019.10.012.Peer-Reviewed Original ResearchA novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
Sun Q, Lee W, Mohri Y, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Gay DL, Saur D, Nishimura EK, Ito M. A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease. Nature Communications 2019, 10: 5023. PMID: 31685822, PMCID: PMC6828673, DOI: 10.1038/s41467-019-12733-1.Peer-Reviewed Original ResearchConceptsMouse modelNovel mouse modelMelanoma progression modelDeadly skin cancerAnimal modelsSkin cancerBona fide sourceAdvanced stageMelanoma inductionMalignant transformationHuman melanomaMelanomaGene signatureAnagen onsetMolecular profilingMelanoma initiationMelanocyte stem cellsNormal WntStem cellsProgression modelHuman diseasesRecent studiesCancerDiseaseProgressionPutting Cell Competition under the Microscope
Levinsohn J, Myung P. Putting Cell Competition under the Microscope. Developmental Cell 2019, 49: 823-824. PMID: 31211989, DOI: 10.1016/j.devcel.2019.05.040.Peer-Reviewed Original Research942 Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Lim C, Sun Q, Ratti K, Lee S, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus M, Cain J, Wang D, Watkins N, Millar S, Taketo M, Myung P, Cotsarelis G, Ito M. 942 Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Journal Of Investigative Dermatology 2019, 139: s163. DOI: 10.1016/j.jid.2019.03.1018.Peer-Reviewed Original Research