2023
Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
Han S, Wang Q, Song Y, Pang M, Ren C, Wang J, Guan D, Xu W, Li F, Wang F, Zhou X, Fernández-Hernando C, Zhang H, Wu D, Ye Z. Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation. IScience 2023, 26: 106613. PMID: 37128603, PMCID: PMC10148154, DOI: 10.1016/j.isci.2023.106613.Peer-Reviewed Original ResearchTherapeutic optionsSTING activationPotential therapeutic optionProgressive neurodegenerative phenotypeNiemann-Pick disease type CGenetic lysosomal disorderNP-C patientsCytosolic calcium concentrationDisease type CEffects of lithiumCerebellar inflammationLithium treatmentMouse modelLithium effectsLysosomal disordersNeurodegenerative phenotypeCalcium concentrationSREBP2 activationDisease phenotypeType CMiceSREBP2 pathwayActivationDeficient fibroblastsPhenotype
2013
PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice
Li H, Park D, Abdul-Muneer P, Xu B, Wang H, Xing B, Wu D, Li S. PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience 2013, 253: 89-99. PMID: 24012746, PMCID: PMC9529370, DOI: 10.1016/j.neuroscience.2013.08.051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCD3 ComplexClass Ib Phosphatidylinositol 3-KinaseDioxolesDisease Models, AnimalEctodysplasinsEncephalomyelitis, Autoimmune, ExperimentalEnzyme InhibitorsGene Expression RegulationMiceMice, Inbred C57BLMice, KnockoutMyelin SheathMyelin-Oligodendrocyte GlycoproteinNeurofilament ProteinsPeptide FragmentsPhosphoinositide-3 Kinase InhibitorsSerotoninSeverity of Illness IndexSpinal CordThiazolidinedionesTime FactorsConceptsExperimental autoimmune encephalomyelitisMultiple sclerosisEAE miceSpinal cordExperimental autoimmune encephalomyelitis (EAE) miceAutoimmune CNS inflammationLumbar spinal cordNumber of axonsCNS inflammationAutoimmune encephalomyelitisSystemic treatmentClinical symptomsPI3Kγ inhibitionInflammatory cellsAxon numberClinical signsInflammatory responseInflammatory reactionKnockout miceFiber tractsMicePI3Kγ inhibitorsCordSymptomsPI3Kγ
2001
Calcium Responses to Thyrotropin-Releasing Hormone, Gonadotropin-Releasing Hormone and Somatostatin in Phospholipase Cβ3 Knockout Mice
Romoser V, Graves T, Wu D, Jiang H, Hinkle P. Calcium Responses to Thyrotropin-Releasing Hormone, Gonadotropin-Releasing Hormone and Somatostatin in Phospholipase Cβ3 Knockout Mice. Endocrinology 2001, 15: 125-135. PMID: 11145744, DOI: 10.1210/mend.15.1.0588.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaBlotting, WesternCalciumCells, CulturedFemaleFluorescent Antibody TechniqueGonadotropin-Releasing HormoneIsoenzymesMaleMiceMice, KnockoutMicroscopy, FluorescenceMuscle, Smooth, VascularPituitary GlandSignal TransductionSomatostatinThyrotropin-Releasing HormoneType C PhospholipasesConceptsWild-type miceKnockout micePituitary cellsSmooth muscle cellsCalcium responseIntracellular calciumMuscle cellsAortic smooth muscle cellsThyrotropin-Releasing HormoneCalcium-mobilizing actionGonadotropin-Releasing HormoneInhibited influxMicroM TRHExtracellular calciumSomatostatinPituitary tissueKnockout animalsMiceHormoneSignal pathwayPLCbeta1Phospholipase CbetaPLCbeta3CalciumGalphaq/11
1996
Phospholipase C β4 is involved in modulating the visual response in mice
Jiang H, Lyubarsky A, Dodd R, Vardi N, Pugh E, Baylor D, Simon M, Wu D. Phospholipase C β4 is involved in modulating the visual response in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14598-14601. PMID: 8962098, PMCID: PMC26179, DOI: 10.1073/pnas.93.25.14598.Peer-Reviewed Original ResearchConceptsPLC-beta 4Beta 4Phospholipase C beta 4Cell-cell interactionsC beta 4Phototransduction cascadePLC-betaRod photoreceptorsPhysiological significanceMouse linesLateral geniculate nucleusPhospholipase C β4Wild-type littermatesElectroretinographic resultsVisual functionGeniculate nucleusLittermate controlsSuperior colliculusRod aRetinal cellsBehavioral testsLight microscopyB-wave componentVisual responsesMice
1993
The transforming activity of activated Gα12
Jiang H, Wu D, Simon M. The transforming activity of activated Gα12. FEBS Letters 1993, 330: 319-322. PMID: 8397105, DOI: 10.1016/0014-5793(93)80896-3.Peer-Reviewed Original Research