2013
PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice
Li H, Park D, Abdul-Muneer P, Xu B, Wang H, Xing B, Wu D, Li S. PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience 2013, 253: 89-99. PMID: 24012746, PMCID: PMC9529370, DOI: 10.1016/j.neuroscience.2013.08.051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCD3 ComplexClass Ib Phosphatidylinositol 3-KinaseDioxolesDisease Models, AnimalEctodysplasinsEncephalomyelitis, Autoimmune, ExperimentalEnzyme InhibitorsGene Expression RegulationMiceMice, Inbred C57BLMice, KnockoutMyelin SheathMyelin-Oligodendrocyte GlycoproteinNeurofilament ProteinsPeptide FragmentsPhosphoinositide-3 Kinase InhibitorsSerotoninSeverity of Illness IndexSpinal CordThiazolidinedionesTime FactorsConceptsExperimental autoimmune encephalomyelitisMultiple sclerosisEAE miceSpinal cordExperimental autoimmune encephalomyelitis (EAE) miceAutoimmune CNS inflammationLumbar spinal cordNumber of axonsCNS inflammationAutoimmune encephalomyelitisSystemic treatmentClinical symptomsPI3Kγ inhibitionInflammatory cellsAxon numberClinical signsInflammatory responseInflammatory reactionKnockout miceFiber tractsMicePI3Kγ inhibitorsCordSymptomsPI3Kγ
2004
PLCβ Is Critical for T-Cell Chemotaxis In Vivo.
Bach T, Chen Q, Jordan M, Choi J, Wu D, Koretzky G, Zigmond S, Abrams C. PLCβ Is Critical for T-Cell Chemotaxis In Vivo. Blood 2004, 104: 2650. DOI: 10.1182/blood.v104.11.2650.2650.Peer-Reviewed Original ResearchT cell migrationT cellsChronic inflammationNeutrophil chemotaxisDense inflammatory infiltrateSecondary lymphoid organsWild-type T cellsType T cellsPeripheral T cellsWild-type miceMonths of ageWild-type lymphocytesT cell chemotaxisCytoplasmic calcium concentrationNull T cellsChemotactic responseKnockout T cellsInflammatory infiltrateRecipient miceLymphoid organsInflammatory responseSkin ulcersQuin-2 AMPlasma cellsT lymphocytes
1993
G Protein-Coupled Signal Transduction Pathways for Interleukin-8
Wu D, LaRosa G, Simon M. G Protein-Coupled Signal Transduction Pathways for Interleukin-8. Science 1993, 261: 101-103. PMID: 8316840, DOI: 10.1126/science.8316840.Peer-Reviewed Original ResearchConceptsIL-8 receptorsInterleukin-8Free beta gamma subunitsPertussis toxin-sensitive G proteinToxin-sensitive G proteinIL-8 actsPhospholipase CSpecific heterotrimeric G proteinsAnti-inflammatory agentsG alpha 15G proteinsG alpha 11G alpha qG alpha 16G protein GiBeta 2 isoformG alpha 14Inflammatory responseAlpha 14Beta gamma subunitsProtein GiAlpha 11Alpha qMajor mediatorAlpha 15