1998
Axon Conduction and Survival in CNS White Matter During Energy Deprivation: A Developmental Study
Fern R, Davis P, Waxman S, Ransom B. Axon Conduction and Survival in CNS White Matter During Energy Deprivation: A Developmental Study. Journal Of Neurophysiology 1998, 79: 95-105. PMID: 9425180, DOI: 10.1152/jn.1998.79.1.95.Peer-Reviewed Original ResearchConceptsAnoxia/aglycemiaCompound action potentialWithdrawal of oxygenOptic nerveCNS white matterWhite matterIsolated rat optic nerveEvoked compound action potentialAdult optic nerveOptic nerve functionRat optic nervePostnatal day 10Permanent lossMin of glucoseEnergy deprivationWithdrawal of glucoseGlucose withdrawalNerve functionAstrocytic glycogenAxon conductionHeightened metabolic activityAdult ratsAglycemiaIrreversible injuryNerve
1990
Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus
O'Regan M, Kocsis J, Waxman S. Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus. Brain Research 1990, 527: 181-191. PMID: 1701335, DOI: 10.1016/0006-8993(90)91136-5.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCaffeineDihydropyridinesEvoked PotentialsFemaleHippocampusIn Vitro TechniquesLightMembrane PotentialsNeuronsNifedipineNimodipinePerfusionPotassiumPyramidal TractsRatsRats, Inbred StrainsSynapsesSynaptic TransmissionConceptsBay K 8644Synaptic transmissionDepressant actionIntracellular recordingsModerate membrane depolarizationMembrane depolarizationHippocampal brain slicesNormal Krebs solutionField potential responsesDepolarization-dependent increaseField potential analysisCA1 neuronsPresynaptic locusHippocampal slicesKrebs solutionPostsynaptic componentsPostsynaptic responsesPyramidal cellsNeuronal excitabilityRat hippocampusBrain slicesDirect depolarizationSpike thresholdDHP effectField potentials
1982
Intra-axonal recordings in rat dorsal column axons: membrane hyperpolarization and decreased excitability precede the primary afferent depolarization
Kocsis J, Waxman S. Intra-axonal recordings in rat dorsal column axons: membrane hyperpolarization and decreased excitability precede the primary afferent depolarization. Brain Research 1982, 238: 222-227. PMID: 6282392, DOI: 10.1016/0006-8993(82)90787-9.Peer-Reviewed Original ResearchConceptsPrimary afferent depolarizationIntra-axonal recordingsRat lumbosacral spinal cordDorsal column stimulationDorsal root potentialsLumbosacral spinal cordDorsal column axonsDorsal columnsDorsal rootsAxonal depolarizationRoot potentialsSpinal cordGABA responsesNeuronal elementsIntracellular correlatesProlonged depolarizationMembrane hyperpolarizationHyperpolarizationDepolarizationExcitability
1981
Basic and clinical electrophysiology of demyelinating diseases.
Ritchie J, Waxman S, Waksman B. Basic and clinical electrophysiology of demyelinating diseases. Neurology 1981, 31: 1308-10. PMID: 6287348, DOI: 10.1212/wnl.31.10.1308.Peer-Reviewed Original ResearchEnhanced parallel fiber frequency-following after reduction of postsynaptic activity
Kocsis J, Malenka R, Waxman S. Enhanced parallel fiber frequency-following after reduction of postsynaptic activity. Brain Research 1981, 207: 321-331. PMID: 6258738, DOI: 10.1016/0006-8993(81)90367-x.Peer-Reviewed Original ResearchMeSH KeywordsAminopyridinesAnimalsCerebellar CortexDendritesElectric StimulationEvoked PotentialsMaleManganeseNerve FibersRatsSynapsesSynaptic TransmissionConceptsCalcium antagonistsSynaptic activityPostsynaptic activityParallel fibersRat cerebellar cortexParallel fiber volleyFiber volleyNeuronal elementsPresynaptic elementsSynaptic potentialsCerebellar cortexLocal superfusionStimulation trainsSlow potentialsEnhancing effectAntagonistExtracellular pathwaysSuperfusionVolleysActivityCortexCerebellum
1980
Ionic channel distribution and heterogeneity of the axon membrane in myelinated fibers.
Waxman S, Foster R. Ionic channel distribution and heterogeneity of the axon membrane in myelinated fibers. Brain Research 1980, 203: 205-34. PMID: 6253027, DOI: 10.1016/0165-0173(80)90008-9.Peer-Reviewed Original ResearchEffects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex
Kocsis J, Malenka R, Waxman S. Effects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex. Brain Research 1980, 195: 511-516. PMID: 6249447, DOI: 10.1016/0006-8993(80)90090-6.Peer-Reviewed Original ResearchMeSH KeywordsAminopyridinesAnimalsCerebellar CortexElectric StimulationEvoked PotentialsMaleNerve FibersNeural ConductionPotassiumRatsSynaptic TransmissionPathophysiology of nerve conduction: relation to diabetic neuropathy.
WAXMAN S. Pathophysiology of nerve conduction: relation to diabetic neuropathy. Annals Of Internal Medicine 1980, 92: 297-301. PMID: 6243892, DOI: 10.7326/0003-4819-92-2-297.Peer-Reviewed Original ResearchConceptsTotal conduction blockProximal-distal gradientClinicopathologic aspectsDiabetic neuropathyClinical deficitsElectrophysiologic variablesNerve diseasePathophysiologic mechanismsNerve conductionConduction blockPathologic basisConduction velocityImpulse conductionTopographic patternsTemporal dispersionNeuropathyNerveDysfunctionPathophysiologyLesionsDisease
1972
Regional differentiation of the axon: A review with special reference to the concept of the multiplex neuron
Waxman S. Regional differentiation of the axon: A review with special reference to the concept of the multiplex neuron. Brain Research 1972, 47: 269-288. PMID: 4345196, DOI: 10.1016/0006-8993(72)90639-7.Peer-Reviewed Original Research
1971
An electron microscopic study of synaptic morphology in the oculomotor nuclei of three inframammalian species
Waxman S, Pappas G. An electron microscopic study of synaptic morphology in the oculomotor nuclei of three inframammalian species. The Journal Of Comparative Neurology 1971, 143: 41-71. PMID: 4329004, DOI: 10.1002/cne.901430105.Peer-Reviewed Original ResearchConceptsOculomotor nucleusOculomotor neuronsLarge neuronsElectrotonic couplingSubjunctional dense bodiesDistribution of synapsesMajority of synapsesSmall-diameter dendritesClose appositionContralateral oculomotor nucleusPrevious electrophysiological studiesDense-core vesiclesMultipolar interneuronsNodes of RanvierAxodendritic synapsesAxosomatic synapsesProximal dendritesClose membrane appositionSynaptic contactsPresynaptic fibersSynaptic profilesGlial elementsSmall interneuronsNeuronal typesGlial lamellae
1969
Oculomotor Neurons in Fish: Electrotonic Coupling and Multiple Sites of Impulse Initiation
Kriebel M, Bennett M, Waxman S, Pappas G. Oculomotor Neurons in Fish: Electrotonic Coupling and Multiple Sites of Impulse Initiation. Science 1969, 166: 520-524. PMID: 4309628, DOI: 10.1126/science.166.3904.520.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEvoked PotentialsFishesMicroscopy, ElectronMuscle ContractionNeuronsOculomotor NerveSynaptic Transmission