2015
Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy
Doppler K, Appeltshauser L, Krämer HH, Ng JK, Meinl E, Villmann C, Brophy P, Dib-Hajj SD, Waxman SG, Weishaupt A, Sommer C. Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. PLOS ONE 2015, 10: e0134274. PMID: 26218529, PMCID: PMC4517860, DOI: 10.1371/journal.pone.0134274.Peer-Reviewed Original ResearchConceptsMultifocal motor neuropathyMotor neuropathyContactin-1Neurofascin 155Multifocal motor neuropathy patientsChronic inflammatory demyelinating polyneuropathyInflammatory demyelinating polyneuropathySubgroup of patientsNeurofascin-186Enzyme-linked immunosorbentHuman embryonic kidney 293 cellsDemyelinating polyneuropathyAuto antibodiesEmbryonic kidney 293 cellsMuscle weaknessNeuropathy patientsPatient seraConduction blockParanodal proteinsNeuropathyPatientsKidney 293 cellsIgMSerumDifferent assays
2012
Gain-of-function Nav1.8 mutations in painful neuropathy
Faber CG, Lauria G, Merkies IS, Cheng X, Han C, Ahn HS, Persson AK, Hoeijmakers JG, Gerrits MM, Pierro T, Lombardi R, Kapetis D, Dib-Hajj SD, Waxman SG. Gain-of-function Nav1.8 mutations in painful neuropathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 19444-19449. PMID: 23115331, PMCID: PMC3511073, DOI: 10.1073/pnas.1216080109.Peer-Reviewed Original ResearchConceptsPainful peripheral neuropathySmall fiber neuropathyPainful neuropathyPeripheral neuropathyPainful small fiber neuropathyDorsal root ganglion neuronsSodium channelsApparent underlying causePeripheral nerve axonsDRG neuronsGanglion neuronsNeuropathyNerve axonsUnderlying causeFunction variantsCurrent clampPatientsPotential pathogenicityNeuronsMutationsHyperexcitabilityAxonsResponse
1995
Clivus and cervical spinal osteomyelitis with epidural abscess presenting with multiple cranial neuropathies
Azizi S, Fayad P, Fulbright R, Giroux M, Waxman S. Clivus and cervical spinal osteomyelitis with epidural abscess presenting with multiple cranial neuropathies. Clinical Neurology And Neurosurgery 1995, 97: 239-244. PMID: 7586856, DOI: 10.1016/0303-8467(95)00036-j.Peer-Reviewed Original ResearchConceptsCranial nerve abnormalitiesNerve abnormalitiesTwelfth nerve palsyMultiple cranial neuropathiesElevated CSF proteinHistory of otitisCranial neuropathiesDiabetic menNerve palsyEpidural abscessShoulder painSpinal osteomyelitisLumbar punctureCervical spinePrevertebral spaceEpidural spaceCSF proteinImaging proceduresClivusOsteomyelitisPatientsAbnormalitiesNeckPleocytosisNeuropathy
1993
Painless aortic dissection presenting as a progressive myelopathy
Holloway S, Fayad P, Kalb R, Guarnaccia J, Waxman S. Painless aortic dissection presenting as a progressive myelopathy. Journal Of The Neurological Sciences 1993, 120: 141-144. PMID: 8138802, DOI: 10.1016/0022-510x(93)90265-z.Peer-Reviewed Original ResearchConceptsPainless aortic dissectionAortic dissectionProgressive myelopathyCentral nervous system ischemiaSpinal cord syndromeThoracic aortic dissectionAbsence of painThoracic vertebral bodyMagnetic resonance imagingTransverse myelopathyCord syndromeNeurologic deficitsNeurologic symptomsIschemic changesEarly recognitionSpinal cordDifferential diagnosisNew therapiesVertebral bodyResonance imagingMyelopathyThoracic vertebraeDissectionPainIschemia
1981
Diabetic Truncal Polyneuropathy
Waxman S, Sabin T. Diabetic Truncal Polyneuropathy. JAMA Neurology 1981, 38: 46-47. PMID: 7458723, DOI: 10.1001/archneur.1981.00510010072013.Peer-Reviewed Original Research
1979
The flexion-adduction sign in neuralgic amyotrophy.
Waxman S. The flexion-adduction sign in neuralgic amyotrophy. Neurology 1979, 29: 1301-4. PMID: 573411, DOI: 10.1212/wnl.29.9_part_1.1301.Peer-Reviewed Original Research
1976
Progressive multifocal neurologic deficit with disseminated subpial demyelination.
Galaburda A, Waxman S, Kemper T, Jones H. Progressive multifocal neurologic deficit with disseminated subpial demyelination. Journal Of Neuropathology & Experimental Neurology 1976, 35: 481-94. PMID: 182927, DOI: 10.1097/00005072-197609000-00001.Peer-Reviewed Original ResearchConceptsMyelin lossAcute urinary retentionModerate mononuclear pleocytosisMultifocal neurologic deficitsDistinct clinical entityYear old manUnusual clinical pictureNormal electrophoretic patternMononuclear pleocytosisUrinary retentionAxonal preservationNeurologic deficitsGait difficultyAstrocytic gliosisClinical entityClinical picturePerivascular cuffingSubpial demyelinationMononuclear cellsMyelinated fibersHistological examinationCerebrospinal fluidGross examinationCoronal sectionsDemyelinationAcute confusional states with right middle cerebral artery infarctions.
Mesulam M, Waxman S, Geschwind N, Sabin T. Acute confusional states with right middle cerebral artery infarctions. Journal Of Neurology Neurosurgery & Psychiatry 1976, 39: 84. PMID: 1255216, PMCID: PMC492219, DOI: 10.1136/jnnp.39.1.84.Peer-Reviewed Original ResearchConceptsAcute confusional stateConfusional stateRight middle cerebral artery infarctionRight middle cerebral arteryMiddle cerebral artery infarctionCerebral artery infarctionMiddle cerebral arteryArtery infarctionCerebral arteryCortical connectionsAssociation cortexMonkey brainHomologous areasInfarctionMain deficitsDeficitsPatientsArteryLesionsCortexBrain
1975
Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma.
Burger R, Waxman S, Gilbert H, Mehlman C, Allen R. Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma. Journal Of Clinical Investigation 1975, 56: 1262-1270. PMID: 171283, PMCID: PMC301989, DOI: 10.1172/jci108202.Peer-Reviewed Original ResearchConceptsVitamin B12-binding proteinsHepatocellular carcinomaR-type proteinNormal liver tissueCertain patientsAdolescent patientsPleural fluidHuman milkSame patientPatientsSialic acid contentTumor tissueImmunologic propertiesLiver tissueSurvival studiesMore sialic acidCarcinomaPlasma survivalHigh levelsSialic acidImmunoprecipitation assaysTissueSodium dodecyl sulfate-polyacrylamide gel electrophoresisDodecyl sulfate-polyacrylamide gel electrophoresisApparent molecular weight
1974
Subacute brain-stem encephalitis
Waxman S, Sabin T, Embree L. Subacute brain-stem encephalitis. Journal Of Neurology Neurosurgery & Psychiatry 1974, 37: 811. PMID: 4854509, PMCID: PMC494788, DOI: 10.1136/jnnp.37.7.811.Peer-Reviewed Original ResearchConceptsPerivascular lymphocytic cuffingBrain stem encephalitisYear old manBrain stem changesMedullary dysfunctionUnderlying malignancyGlial nodulesLymphocytic cuffingLateral gazeMicroglial infiltrationPathological examinationBilateral paralysisProgressive signsRespiratory deathsGeneral diseasesOlder menImmunity mechanismsDysphagiaNeuronophagiaCuffingEncephalitisPontineMalignancyDysfunctionDysarthria