2018
Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner
Li Y, Zhu T, Yang H, Dib-Hajj S, Waxman S, Yu Y, Xu TL, Cheng X. Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner. Molecular Pain 2018, 14: 1744806918782229. PMID: 29790812, PMCID: PMC6024516, DOI: 10.1177/1744806918782229.Peer-Reviewed Original ResearchConceptsND7/23 cellsDRG neuron excitabilityModulation of Nav1.7New pain therapeuticsVoltage-gated sodium channel Nav1.7Fyn kinaseWhole-cell recordingsSodium channel Nav1.7Elevated protein expressionCell type-specific modulationHuman embryonic kidney 293 cellsTyrosine kinasePain disordersEmbryonic kidney 293 cellsPain therapeuticsNeuron excitabilityPain perceptionMutant channelsChannel Nav1.7Kidney 293 cellsNav1.7HEK-293 cellsNav1.7 channelsCell type-dependent mannerType-dependent manner
2001
Glycosylation Alters Steady-State Inactivation of Sodium Channel Nav1.9/NaN in Dorsal Root Ganglion Neurons and Is Developmentally Regulated
Tyrrell L, Renganathan M, Dib-Hajj S, Waxman S. Glycosylation Alters Steady-State Inactivation of Sodium Channel Nav1.9/NaN in Dorsal Root Ganglion Neurons and Is Developmentally Regulated. Journal Of Neuroscience 2001, 21: 9629-9637. PMID: 11739573, PMCID: PMC6763018, DOI: 10.1523/jneurosci.21-24-09629.2001.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornAntibody SpecificityAxotomyCell MembraneCells, CulturedFemaleGanglia, SpinalGlycosylationImmunoblottingMembrane PotentialsN-Acetylneuraminic AcidNAV1.9 Voltage-Gated Sodium ChannelNeuraminidaseNeuronsNeuropeptidesPatch-Clamp TechniquesRatsRats, Sprague-DawleySciatic NerveSodiumSodium ChannelsSubcellular FractionsTetrodotoxinTrigeminal GanglionConceptsImmunoreactive proteinMembrane fractionAdult DRG neuronsTranscription-PCR analysisHigh molecular weight immunoreactive proteinTheoretical molecular weightWhole-cell patch-clamp analysisLong transcriptsGlycosylation statePatch-clamp analysisAdult tissuesLarge proteinsLimited glycosylationEnzymatic deglycosylationExtensive glycosylationState of glycosylationProteinAdult dorsal root gangliaGlycosylationNative neuronsDevelopmental changesInactivationMembrane preparationsDRG neuronsDorsal root gangliaDirect Interaction with Contactin Targets Voltage-gated Sodium Channel Nav1.9/NaN to the Cell Membrane*
Liu C, Dib-Hajj S, Black J, Greenwood J, Lian Z, Waxman S. Direct Interaction with Contactin Targets Voltage-gated Sodium Channel Nav1.9/NaN to the Cell Membrane*. Journal Of Biological Chemistry 2001, 276: 46553-46561. PMID: 11581273, DOI: 10.1074/jbc.m108699200.Peer-Reviewed Original ResearchConceptsDorsal root gangliaRoot gangliaSodium channelsSmall sensory neuronsVoltage-gated sodium channelsTrigeminal ganglionNerve endingsC-fibersSensory neuronsNeuron somataChinese hamster ovary cell lineDifferent physiological propertiesGangliaHamster ovary cell lineNeuronal membranesChinese hamster ovary cellsOvary cell lineProtein complexesSurface expressionHamster ovary cellsCell linesAxonsSurface localizationCell membraneOvary cells
1988
Unmyelinated and myelinated axon membrane from rat corpus callosum: differences in macromolecular structure
Waxman S, Black J. Unmyelinated and myelinated axon membrane from rat corpus callosum: differences in macromolecular structure. Brain Research 1988, 453: 337-343. PMID: 3401771, DOI: 10.1016/0006-8993(88)90174-6.Peer-Reviewed Original ResearchRegional membrane heterogeneity in premyelinated CNS axons: factors influencing the binding of sterol-specific probes
Fields R, Waxman S. Regional membrane heterogeneity in premyelinated CNS axons: factors influencing the binding of sterol-specific probes. Brain Research 1988, 443: 231-242. PMID: 3359268, DOI: 10.1016/0006-8993(88)91617-4.Peer-Reviewed Original Research
1987
Macromolecular structure of the Schwann cell membrane Perinodal microvilli
Waxman S, Black J. Macromolecular structure of the Schwann cell membrane Perinodal microvilli. Journal Of The Neurological Sciences 1987, 77: 23-34. PMID: 3806135, DOI: 10.1016/0022-510x(87)90203-6.Peer-Reviewed Original Research
1986
Differences in intramembranous particle distribution in the paranodal axolemma are not associated with functional differences of dorsal and ventral roots
Fields R, Black J, Bowe C, Kocsis J, Waxman S. Differences in intramembranous particle distribution in the paranodal axolemma are not associated with functional differences of dorsal and ventral roots. Neuroscience Letters 1986, 67: 13-18. PMID: 2425295, DOI: 10.1016/0304-3940(86)90200-4.Peer-Reviewed Original Research
1985
Axo-glial relations in the retina-optic nerve junction of the adult rat: freeze-fracture observations on axon membrane structure
Black J, Waxman S, Hildebrand C. Axo-glial relations in the retina-optic nerve junction of the adult rat: freeze-fracture observations on axon membrane structure. Brain Cell Biology 1985, 14: 887-907. PMID: 3831245, DOI: 10.1007/bf01224803.Peer-Reviewed Original ResearchOrganization of Ion Channels in the Myelinated Nerve Fiber
Waxman S, Ritchie J. Organization of Ion Channels in the Myelinated Nerve Fiber. Science 1985, 228: 1502-1507. PMID: 2409596, DOI: 10.1126/science.2409596.Peer-Reviewed Original ResearchSpecialization of astrocytic membrane at glia limitans in rat optic nerve: Freeze-fracture observations
Black J, Waxman S. Specialization of astrocytic membrane at glia limitans in rat optic nerve: Freeze-fracture observations. Neuroscience Letters 1985, 55: 371-378. PMID: 4011040, DOI: 10.1016/0304-3940(85)90464-1.Peer-Reviewed Original Research
1984
Membrane specialization and axo-glial association in the rat retinal nerve fibre layer: freeze-fracture observations
Black J, Waxman S, Hildebrand C. Membrane specialization and axo-glial association in the rat retinal nerve fibre layer: freeze-fracture observations. Brain Cell Biology 1984, 13: 417-430. PMID: 6481406, DOI: 10.1007/bf01148332.Peer-Reviewed Original Research
1981
Electrophysiology of demyelinating diseases: future directions and questions.
Waxman S, Ritchie J. Electrophysiology of demyelinating diseases: future directions and questions. Advances In Neurology 1981, 31: 511-13. PMID: 6275675.Peer-Reviewed Original ResearchClinicopathological correlations in multiple sclerosis and related diseases.
Waxman S. Clinicopathological correlations in multiple sclerosis and related diseases. Advances In Neurology 1981, 31: 169-82. PMID: 7325041.Peer-Reviewed Original Research
1977
Conduction in Myelinated, Unmyelinated, and Demyelinated Fibers
Waxman S. Conduction in Myelinated, Unmyelinated, and Demyelinated Fibers. JAMA Neurology 1977, 34: 585-589. PMID: 907529, DOI: 10.1001/archneur.1977.00500220019003.Peer-Reviewed Original ResearchCytochemical differentiation of the axon membrane in A- and C-fibres.
Waxman S, Quick D. Cytochemical differentiation of the axon membrane in A- and C-fibres. Journal Of Neurology Neurosurgery & Psychiatry 1977, 40: 379. PMID: 327027, PMCID: PMC492705, DOI: 10.1136/jnnp.40.4.379.Peer-Reviewed Original ResearchSpecific staining of the axon membrane at nodes of Ranvier with ferric ion and ferrocyanide
Quick D, Waxman S. Specific staining of the axon membrane at nodes of Ranvier with ferric ion and ferrocyanide. Journal Of The Neurological Sciences 1977, 31: 1-11. PMID: 64593, DOI: 10.1016/0022-510x(77)90002-8.Peer-Reviewed Original Research
1974
Ultrastructural differentiation of the axon membrane at synaptic and non-synaptic central nodes of Ranvier
Waxman S. Ultrastructural differentiation of the axon membrane at synaptic and non-synaptic central nodes of Ranvier. Brain Research 1974, 65: 338-342. PMID: 4472521, DOI: 10.1016/0006-8993(74)90046-8.Peer-Reviewed Original Research
1968
Micropinocytotic invaginations in the axolemma of peripheral nerves
Waxman S. Micropinocytotic invaginations in the axolemma of peripheral nerves. Cell And Tissue Research 1968, 86: 571-573. PMID: 5707296, DOI: 10.1007/bf00324867.Peer-Reviewed Original Research