1999
Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
Fjell J, Cummins T, Dib-Hajj S, Fried K, Black J, Waxman S. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Brain Research 1999, 67: 267-282. PMID: 10216225, DOI: 10.1016/s0169-328x(99)00070-4.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAxotomyCell SizeCell SurvivalDown-RegulationDrug ResistanceFemaleGanglia, SpinalGene ExpressionGlial Cell Line-Derived Neurotrophic FactorLectinsMembrane PotentialsNAV1.8 Voltage-Gated Sodium ChannelNAV1.9 Voltage-Gated Sodium ChannelNerve Growth FactorsNerve Tissue ProteinsNeurons, AfferentNeuropeptidesPatch-Clamp TechniquesRatsRats, Sprague-DawleyRNA, MessengerSciatic NerveSodium ChannelsTetrodotoxinUp-RegulationConceptsTTX-R sodium currentsSNS/PN3Small DRG neuronsTTX-R currentsDRG neuronsIB4- neuronsSodium currentElectrophysiological propertiesSmall dorsal root ganglion neuronsDorsal root ganglion neuronsAxotomized DRG neuronsTTX-S currentsWhole-cell patch-clamp studiesTTX-resistant sodium channelsSciatic nerve transectionAdult DRG neuronsDifferent electrophysiological propertiesNear-normal levelsPatch-clamp studiesNerve transectionGDNF treatmentNeurotrophins NGFGanglion neuronsIsolectin IB4Exogenous NGF
1997
Downregulation of Na+ channel mRNA in olfactory bulb tufted cells following deafferentiation
Sashihara S, Waxman S, Greer C. Downregulation of Na+ channel mRNA in olfactory bulb tufted cells following deafferentiation. Neuroreport 1997, 8: 1289-1293. PMID: 9175131, DOI: 10.1097/00001756-199703240-00046.Peer-Reviewed Original ResearchConceptsOlfactory bulbMitral cellsEffects of deafferentationPostnatal day 2Olfactory receptor cellsFunctional deafferentationAfferent inputChannel expressionDay 2Channel mRNAReceptor cellsChannel subunitsDeafferentationI mRNACauterizationCritical periodDetectable changeAlpha IIOdorant accessSitu hybridizationCellsCell propertiesExpressionBulbMRNA