2023
Targeting a Peripheral Sodium Channel to Treat Pain
Waxman S. Targeting a Peripheral Sodium Channel to Treat Pain. New England Journal Of Medicine 2023, 389: 466-469. PMID: 37530829, DOI: 10.1056/nejme2305708.Peer-Reviewed Original ResearchConceptsPeripheral sodium channelsAcute postoperative painSodium channelsSodium channel Nav1.8Peripheral painPostoperative painClinical trialsPainNav1.8Trials
2019
Sodium Channels and Pain
Cummins T, Waxman S, Wood J. Sodium Channels and Pain. 2019, 233-262. DOI: 10.1093/oxfordhb/9780190860509.013.3.Peer-Reviewed Original ResearchSodium channel blockersPain conditionsChannel blockersSodium channelsAnalgesic drug targetsDifferent pain statesFunction Nav1.7 mutationsMost pain conditionsPeripheral sodium channelsSodium channel subtypesDamage-sensing neuronsDrug developmentVoltage-gated sodium channelsSodium channel isoformsDrug development programsIon channelsExcellent analgesicPain controlPain reliefPain statesNav1.7 mutationSodium-selective ion channelsNew analgesicsLocal anestheticsTherapeutic approaches