1998
Axon Conduction and Survival in CNS White Matter During Energy Deprivation: A Developmental Study
Fern R, Davis P, Waxman S, Ransom B. Axon Conduction and Survival in CNS White Matter During Energy Deprivation: A Developmental Study. Journal Of Neurophysiology 1998, 79: 95-105. PMID: 9425180, DOI: 10.1152/jn.1998.79.1.95.Peer-Reviewed Original ResearchConceptsAnoxia/aglycemiaCompound action potentialWithdrawal of oxygenOptic nerveCNS white matterWhite matterIsolated rat optic nerveEvoked compound action potentialAdult optic nerveOptic nerve functionRat optic nervePostnatal day 10Permanent lossMin of glucoseEnergy deprivationWithdrawal of glucoseGlucose withdrawalNerve functionAstrocytic glycogenAxon conductionHeightened metabolic activityAdult ratsAglycemiaIrreversible injuryNerve
1996
White Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications
Fern R, Ransom B, Waxman S. White Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications. Cerebrovascular Diseases 1996, 6: 59-65. DOI: 10.1159/000107999.Peer-Reviewed Original ResearchWhite matterAnoxic injuryWhite matter strokeIncidence of strokeCNS white matterLevels of GABARecovery of functionResult of anoxiaIrreversible dysfunctionAnoxic insultPharmacological strategiesIrreversible injuryTherapeutic implicationsEndogenous storesExogenous GABAInjuryGABAAutoprotective mechanismsStrokeIntracellular eventsExtracellular spaceCa2Protective treatmentAdenosineInfluxAutoprotective mechanisms in the CNS
Fern R, Ransom B, Waxman S. Autoprotective mechanisms in the CNS. Journal Of Molecular Neuroscience 1996, 27: 107-129. PMID: 8962597, DOI: 10.1007/bf02815088.Peer-Reviewed Original Research
1995
Endogenous GABA attenuates CNS white matter dysfunction following anoxia
Fern R, Waxman S, Ransom B. Endogenous GABA attenuates CNS white matter dysfunction following anoxia. Journal Of Neuroscience 1995, 15: 699-708. PMID: 7823173, PMCID: PMC6578328, DOI: 10.1523/jneurosci.15-01-00699.1995.Peer-Reviewed Original ResearchConceptsCompound action potentialEffect of GABAWhite matterEndogenous GABA releaseNerve fiber injuryGABA-B antagonistRelease of GABACAP recoveryGABA-B receptorsCNS white matterPertussis toxin treatmentWhite matter dysfunctionGABA-A agonistHigh agonist concentrationsReceptor/G-proteinControl conditionG proteinsPresence of GABAMin of anoxiaMM nipecotic acidFiber injuryGABA releaseReceptor blockadeOptic nerveEndogenous GABA
1993
Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium
Waxman S, Black J, Ransom B, Stys P. Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium. Brain Research 1993, 614: 137-145. PMID: 8348309, DOI: 10.1016/0006-8993(93)91027-p.Peer-Reviewed Original ResearchConceptsArtificial cerebrospinal fluidMin of anoxiaOptic nerveZero-Ca2White matterAnoxic injuryCNS white matter tractAxonal cytoskeletonOptic nerve axonsCNS white matterRat optic nerveInflux of Ca2White matter tractsLoss of cristaeDisorganization of cristaeMembranous profilesUltrastructure of axonsAbnormal influxCerebrospinal fluidExtracellular calciumNerveMyelinated axonsNerve axonsNormal Ca2Axons
1992
Effects of Temperature on Evoked Electrical Activity and Anoxic Injury in CNS White Matter
Stys P, Waxman S, Ransom B. Effects of Temperature on Evoked Electrical Activity and Anoxic Injury in CNS White Matter. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 977-986. PMID: 1400652, DOI: 10.1038/jcbfm.1992.135.Peer-Reviewed Original ResearchConceptsFunctional recoveryWhite matterAnoxic injuryMin of anoxiaOptic nerveFunctional outcomeTypical CNS white matter tractAnoxic exposureIntracellular Ca2Anoxic/ischemic injuryCNS white matter tractCompound action potential areaGray matterIsolated rat optic nerveGreater functional recoveryEvoked electrical activityAction potential areaCNS white matterRat optic nerveWhite matter tractsFunctional injuryIschemic injuryPathological increaseAnoxic damageCAP peakUltrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve
Waxman S, Black J, Stys P, Ransom B. Ultrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve. Brain Research 1992, 574: 105-119. PMID: 1638387, DOI: 10.1016/0006-8993(92)90806-k.Peer-Reviewed Original ResearchConceptsOptic nerveRat optic nerveMin of anoxiaPost-anoxic recoveryAnoxic injuryAstrocyte processesMyelin sheathLoss of microtubulesCell-mediated damageCNS white matterInflux of calciumLarge-diameter axonsPrevious electrophysiological studiesAction potential conductionWhite matter tractsNodes of RanvierAnoxic insultUltrastructure of axonsGlial cellsVesicular degenerationConduction blockEarly recoveryElectrophysiological studiesNerveSignificant injuryIonic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger
Stys P, Waxman S, Ransom B. Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. Journal Of Neuroscience 1992, 12: 430-439. PMID: 1311030, PMCID: PMC6575619, DOI: 10.1523/jneurosci.12-02-00430.1992.Peer-Reviewed Original ResearchConceptsRat optic nerveCompound action potentialAnoxic injuryOptic nerveWhite matterAction potentialsCentral white matter tractsWhite matter injuryCNS white matterMembrane depolarizationAnoxia/ischemiaWhite matter tractsCNS protectionAnoxic insultMyelinated tractsChannel blockersExchanger blockerIrreversible injuryExtracellular Ca2Mammalian CNSNerveInjuryMore injuriesBlockersFunctional integrity
1991
Non-synaptic mechanisms of Ca2+-mediated injury in CNS white matter
Waxman S, Ransom B, Stys P. Non-synaptic mechanisms of Ca2+-mediated injury in CNS white matter. Trends In Neurosciences 1991, 14: 461-468. PMID: 1722366, DOI: 10.1016/0166-2236(91)90046-w.Peer-Reviewed Original Research
1990
Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia
Stys P, Ransom B, Waxman S. Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia. Neuroscience Letters 1990, 115: 293-299. PMID: 2234507, DOI: 10.1016/0304-3940(90)90471-k.Peer-Reviewed Original ResearchConceptsAnoxic injuryChannel blockersWhite matterMammalian central white matterDihydropyridine calcium channel blockerChannel blockers Mn2Irreversible anoxic injuryCalcium channel blockersCNS white matterCompound action potentialCentral white matterDihydropyridine classOrganic Ca2Inorganic Ca2Extracellular Ca2Action potentialsNerve modelMin periodBlockersInjuryFunctional integrityConventional Ca2Ca2InfluxIntracellular compartments
1987
Carbonic anhydrase activity develops postnatally in the rat optic nerve
Davis P, Carlini W, Ransom B, Black J, Waxman S. Carbonic anhydrase activity develops postnatally in the rat optic nerve. Brain Research 1987, 31: 291-298. DOI: 10.1016/0165-3806(87)90126-x.Peer-Reviewed Original ResearchRat optic nerveCNS white matterPhysiological alterationsLarger acid shiftDays of ageNeonatal nervesOlder nervesNerve 5Optic nervePostnatal dayWhite matterCarbonic anhydrase activityNerveNeural activityCA activityAgeOligodendrocytesAcid shiftMitotic inhibitorsMyelinAlterationsDaysEnzyme activityActivityOligodendrogliogenesis