TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219)
Nickerson K, Christensen S, Cullen J, Meng W, Luning Prak E, Shlomchik M. TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219). The Journal Of Immunology 2014, 192: 46.10-46.10. DOI: 10.4049/jimmunol.192.supp.46.10.Peer-Reviewed Original ResearchAnti-DNA B cellsSystemic lupus erythematosusB cellsB cell receptorAnti-DNA autoantibodiesLupus erythematosusBreaking B-cell toleranceAbsence of TLR9Reactive B cellsAutoimmunity in vivoB cell toleranceAutoimmune-prone MRLFunctional anergyAutoreactive cellsPeripheral repertoireAnergic cellsBone marrowExtrafollicular pathwayReceptor editingClinical hallmarkBCR signalingMouse modelBCR expressionTLR9Healthy individuals