2014
Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota
Gagliani N, Palm NW, de Zoete MR, Flavell RA. Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota. International Immunology 2014, 26: 495-499. PMID: 24948595, PMCID: PMC4200027, DOI: 10.1093/intimm/dxu066.Peer-Reviewed Original ResearchConceptsIntestinal homeostasisInflammatory responsePathological tissue damageImmediate inflammatory responseConflicting studiesEnteric infectionsIntestinal microbiotaTissue damageInflammasome deficiencyInflammasomeStress-associated signalsInfectionPotential roleMicrobiotaHomeostasisCytosolic protein complexesRecent studies
2013
Inflammasomes and Mucosal Immune Response
Elinav E, Henao-Mejia J, Flavell R. Inflammasomes and Mucosal Immune Response. Else Kröner-Fresenius Symposia 2013, 4: 48-52. DOI: 10.1159/000346510.Peer-Reviewed Original ResearchProtein complexesImmune responseDamage signalsCritical regulatorMolecular characterizationContext of infectionInnate immune responseCell deathMucosal immune responsesMicrobial infectionsPotent inflammatory cytokineCaspase-1Direct activationInflammatory cytokinesSterile inflammationMetabolic disordersInflammasome resultsDiverse rangeInflammasomeKey componentRegulatorInfectionProteinNLRC4AIM2
2011
Inflammasomes in Inflammatory Bowel Disease
Strowig T, Flavell R. Inflammasomes in Inflammatory Bowel Disease. 2011, 111-118. DOI: 10.1007/978-1-4614-0998-4_7.Peer-Reviewed Original ResearchPathogen-derived moleculesAssembly of inflammasomesMultiprotein complexesSensor proteinsInflammatory caspasesMature formDistinct familiesDiverse mechanismsInflammasome functionAntimicrobial defenseDisease mechanismsEndogenous moleculesCaspase-1Pathological conditionsPotent cytokineInflammasome componentsInflammasome activityAssemblyImmune systemInflammasomeInflammatory bowel diseaseCaspasesType II diabetesAuto-inflammatory diseasesProtein