2022
Human neutrophil development and functionality are enabled in a humanized mouse model
Zheng Y, Sefik E, Astle J, Karatepe K, Öz HH, Solis AG, Jackson R, Luo HR, Bruscia EM, Halene S, Shan L, Flavell RA. Human neutrophil development and functionality are enabled in a humanized mouse model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2121077119. PMID: 36269862, PMCID: PMC9618085, DOI: 10.1073/pnas.2121077119.Peer-Reviewed Original ResearchConceptsHumanized mouse modelMouse modelHuman immune systemHuman neutrophilsImmune systemFunctional human immune systemGranulocyte colony-stimulating factorUnique mouse modelColony-stimulating factorHuman G-CSFMISTRG miceG-CSF receptor geneBacterial burdenInfectious challengeG-CSFNeutrophilsMiceNeutrophil developmentReceptor geneDiseaseN‐Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
Cho W, York AG, Wang R, Wyche TP, Piizzi G, Flavell RA, Crawford JM. N‐Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling. ChemBioChem 2022, 23: e202200490-e202200490. PMID: 36112057, PMCID: PMC9762135, DOI: 10.1002/cbic.202200490.Peer-Reviewed Original ResearchConceptsN-acyl amidesGram-negative opportunistic pathogenNeisseria meningitidisHuman-associated bacteriaBlood-brain barrierBioactive small moleculesInterleukin-10 signalingMacrophage cell typesN-acyltransferaseInterleukin-17AG proteinsHuman diseasesT cellsReceptor signalingCell typesImmune systemHigh mortalityHuman microbiotaRepresentative membersOpportunistic pathogenMeningitidisSignalingSmall moleculesN.Meningitis
2012
Humanized mouse models of infectious diseases
Strowig T, Flavell R. Humanized mouse models of infectious diseases. Drug Discovery Today Disease Models 2012, 9: e11-e16. DOI: 10.1016/j.ddmod.2011.10.004.Peer-Reviewed Original Research
2011
Inflammasomes in Inflammatory Bowel Disease
Strowig T, Flavell R. Inflammasomes in Inflammatory Bowel Disease. 2011, 111-118. DOI: 10.1007/978-1-4614-0998-4_7.Peer-Reviewed Original ResearchPathogen-derived moleculesAssembly of inflammasomesMultiprotein complexesSensor proteinsInflammatory caspasesMature formDistinct familiesDiverse mechanismsInflammasome functionAntimicrobial defenseDisease mechanismsEndogenous moleculesCaspase-1Pathological conditionsPotent cytokineInflammasome componentsInflammasome activityAssemblyImmune systemInflammasomeInflammatory bowel diseaseCaspasesType II diabetesAuto-inflammatory diseasesProtein