NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis. Cell 2011, 145: 745-757. PMID: 21565393, PMCID: PMC3140910, DOI: 10.1016/j.cell.2011.04.022.Peer-Reviewed Original ResearchConceptsDextran sodium sulfateDamage-associated molecular patternsIL-18 levelsInflammatory cell recruitmentInflammasome-deficient miceWild-type miceColonic microbial ecologyMouse colonic epithelial cellsColonic epithelial cellsColitogenic activityDSS colitisHuman IBDChemical colitisIL-18Antibiotic treatmentInflammasome pathwayNLRP6 inflammasomeCell recruitmentIntestinal hyperplasiaColitisCaspase-1Fecal microbiotaMolecular patternsEpithelial cellsExacerbation