2013
Inflammasomes and Mucosal Immune Response
Elinav E, Henao-Mejia J, Flavell R. Inflammasomes and Mucosal Immune Response. Else Kröner-Fresenius Symposia 2013, 4: 48-52. DOI: 10.1159/000346510.Peer-Reviewed Original ResearchProtein complexesImmune responseDamage signalsCritical regulatorMolecular characterizationContext of infectionInnate immune responseCell deathMucosal immune responsesMicrobial infectionsPotent inflammatory cytokineCaspase-1Direct activationInflammatory cytokinesSterile inflammationMetabolic disordersInflammasome resultsDiverse rangeInflammasomeKey componentRegulatorInfectionProteinNLRC4AIM2
2011
Inflammasomes in Inflammatory Bowel Disease
Strowig T, Flavell R. Inflammasomes in Inflammatory Bowel Disease. 2011, 111-118. DOI: 10.1007/978-1-4614-0998-4_7.Peer-Reviewed Original ResearchPathogen-derived moleculesAssembly of inflammasomesMultiprotein complexesSensor proteinsInflammatory caspasesMature formDistinct familiesDiverse mechanismsInflammasome functionAntimicrobial defenseDisease mechanismsEndogenous moleculesCaspase-1Pathological conditionsPotent cytokineInflammasome componentsInflammasome activityAssemblyImmune systemInflammasomeInflammatory bowel diseaseCaspasesType II diabetesAuto-inflammatory diseasesProteinNLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis. Cell 2011, 145: 745-757. PMID: 21565393, PMCID: PMC3140910, DOI: 10.1016/j.cell.2011.04.022.Peer-Reviewed Original ResearchConceptsDextran sodium sulfateDamage-associated molecular patternsIL-18 levelsInflammatory cell recruitmentInflammasome-deficient miceWild-type miceColonic microbial ecologyMouse colonic epithelial cellsColonic epithelial cellsColitogenic activityDSS colitisHuman IBDChemical colitisIL-18Antibiotic treatmentInflammasome pathwayNLRP6 inflammasomeCell recruitmentIntestinal hyperplasiaColitisCaspase-1Fecal microbiotaMolecular patternsEpithelial cellsExacerbation