2021
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
Harrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors MA, Lopez‐Cruzan M, Macchiarini F, Nelson JF, Markewych A, Bitto A, Sindler AL, Cortopassi G, Kavanagh K, Leng L, Bucala R, Rosenthal N, Salmon A, Stearns TM, Bogue M, Miller RA. 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Aging Cell 2021, 20: e13328. PMID: 33788371, PMCID: PMC8135004, DOI: 10.1111/acel.13328.Peer-Reviewed Original Research
2012
1240 A FUNCTIONAL ROLE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) FOR FATTY LIVER DISEASE AND OBESITY IN MICE
Heinrichs D, Knauel M, Nellen A, Trautwein C, Bucala R, Bernhagen J, Wasmuth H. 1240 A FUNCTIONAL ROLE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) FOR FATTY LIVER DISEASE AND OBESITY IN MICE. Journal Of Hepatology 2012, 56: s491. DOI: 10.1016/s0168-8278(12)61252-5.Peer-Reviewed Original ResearchA functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase
Heinrichs D, Knauel M, Nellen A, Schmitz P, Trautwein C, Bucala R, Bernhagen J, Wasmuth H. A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase. Zeitschrift Für Gastroenterologie 2012, 50 DOI: 10.1055/s-0031-1295805.Peer-Reviewed Original Research
2006
634: Mice with a Null Mutation For Macrophage Migration Inhibitory Factor Have Lower Stage Tumors in a Mouse Model of Bladder Cancer
Taylor J, Kuchel G, Hegde P, Voznesensky O, Sasso D, Claffey K, Bucala R, Pilbeam C. 634: Mice with a Null Mutation For Macrophage Migration Inhibitory Factor Have Lower Stage Tumors in a Mouse Model of Bladder Cancer. Journal Of Urology 2006, 175: 204. DOI: 10.1016/s0022-5347(18)32880-5.Peer-Reviewed Original Research
2005
Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo
Lee A, Cerami A, Bucala R. Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo. 2005, 249-253. DOI: 10.1533/9781845698393.4.249.Peer-Reviewed Original ResearchEukaryotic model systemsMammalian systemsTransgenic embryosTransgenic miceSignificant genetic alterationsDNA mutationsDNA damageBiological integrityGenetic alterationsMaternal environmentMutation frequencyModel systemNucleic acidsMutationsVitroVivoFunctional activityLacI.Nonenzymatic glycosylationEmbryosGlycosylationLacI mutation frequencyDNAComparative analysisMice
2001
Lysozyme Enhances Renal Excretion of Advanced Glycation Endproducts In Vivo and Suppresses Adverse AGE-mediated Cellular Effects In Vitro: A Potential AGE Sequestration Therapy for Diabetic Nephropathy?
Zheng F, Cai W, Mitsuhashi T, Vlassara H, Bucala R. Lysozyme Enhances Renal Excretion of Advanced Glycation Endproducts In Vivo and Suppresses Adverse AGE-mediated Cellular Effects In Vitro: A Potential AGE Sequestration Therapy for Diabetic Nephropathy? Molecular Medicine 2001, 7: 737-747. PMID: 11788787, PMCID: PMC1950004, DOI: 10.1007/bf03401963.Peer-Reviewed Original ResearchConceptsAdvanced glycation endproductsSerum advanced glycation endproductsDb/db miceNon-obese diabeticSerum AGEsMesangial cellsDb miceAGE-BSAGlycation endproductsIGF-I productionDiabetic renal damageSprague-Dawley ratsAGE clearanceSuppress macrophagesNOD miceDiabetic nephropathyRenal damageRenal excretionNormal ratsMMP-9Type IV collagenHost defense proteinsExcretionMRNA levelsMiceRegulation of the CTL Response by Macrophage Migration Inhibitory Factor
Abe R, Peng T, Sailors J, Bucala R, Metz C. Regulation of the CTL Response by Macrophage Migration Inhibitory Factor. The Journal Of Immunology 2001, 166: 747-753. PMID: 11145646, DOI: 10.4049/jimmunol.166.2.747.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdoptive TransferAnimalsAntibodies, MonoclonalCD8-Positive T-LymphocytesCell MovementCells, CulturedCytotoxicity Tests, ImmunologicCytotoxicity, ImmunologicFemaleInjections, IntraperitonealLymphocytes, Tumor-InfiltratingMacrophage Migration-Inhibitory FactorsMiceMice, Inbred C57BLNeoplasm TransplantationThymomaT-Lymphocytes, CytotoxicTumor Cells, CulturedConceptsMacrophage migration inhibitory factorMigration inhibitory factorTumor-bearing miceCTL activityCTL responsesT lymphocytesAnti-tumor T lymphocytesInhibitory factorCultures of splenocytesApoptotic tumor cellsT cell survivalIL-2RPivotal cytokineT cellsHistological examinationImmune responseIFN-gammaSplenocyte culturesAg stimulationMouse modelTumor growthTumor tissueTumor cellsMiceElevated expression
1994
Comparative analysis of DNA mutations in lacI transgenic mice with age
Lee A, Desimone C, Cerami A, Bucala R. Comparative analysis of DNA mutations in lacI transgenic mice with age. The FASEB Journal 1994, 8: 545-550. PMID: 8181674, DOI: 10.1096/fasebj.8.8.8181674.Peer-Reviewed Original Research