2022
Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells
Kantrong N, Chang AM, Bamashmous S, Hajjar AM, Bucala RJ, Darveau RP. Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells. The Journal Of Periodontology 2022, 93: 1940-1950. PMID: 35100435, DOI: 10.1002/jper.21-0598.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorGingival epithelial cellsIL-8/CXCL8Migration inhibitory factorGingival tissuesJunctional epitheliumGingival epitheliumRole of MIFInhibitory factorMIF KO miceEpithelial cellsExpression of TLR4Healthy gingival tissuesToll-like receptorsInterleukin-1 receptorRepertoire of receptorsOral healthNeutrophil chemoattractantIL-1R1IL-1R2Neutrophil regulationKO micePeriodontal tissuesIL-1ROral homeostasis
2012
40. Antidepressant effects of macrophage migration inhibitory factor using a knockout mouse approach
Bay-Richter C, Janelidze S, Bucala R, Deierborg T, Brundin L. 40. Antidepressant effects of macrophage migration inhibitory factor using a knockout mouse approach. Brain Behavior And Immunity 2012, 26: s11-s12. DOI: 10.1016/j.bbi.2012.07.064.Peer-Reviewed Original ResearchSucrose preference testAntidepressant effectsIL-1βIL-6Male KOMacrophage migration inhibitory factorClear antidepressant effectMIF knockout miceLevels of IFNBrain mRNA expressionMigration inhibitory factorSuppression of IFNIL-6 mRNAIL-12p70Immune alterationsIL-10Female KOPlasma levelsSwim testKO miceSucrose preferenceDepressed patientsWildtype miceKO animalsWildtype littermates