Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through αIIbβ3 and collagen receptors
Judd B, Myung P, Leng L, Obergfell A, Pear W, Shattil S, Koretzky G. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through αIIbβ3 and collagen receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 12056-12061. PMID: 11050236, PMCID: PMC17293, DOI: 10.1073/pnas.97.22.12056.Peer-Reviewed Original ResearchConceptsSLP-76Alpha IIbAdapter protein SLP-76SLP-76 functionSLP-76-deficient miceRapid tyrosine phosphorylationSLP-76-deficient plateletsTyrosine phosphorylated proteinsCollagen receptorCollagen receptor signalingT cell developmentPlatelet fibrinogen receptorPhosphorylated proteinsActin rearrangementCell peripheryLamellipodial extensionTyrosine phosphorylationCell developmentMurine plateletsRetroviral transductionReceptor signalingBind fibrinogenHematopoietic cellsFibrinogen receptorPlatelet-bound fibrinogenIn vitro and in vivo macrophage function can occur independently of SLP-76
Myung PS, Clements JL, White DW, Malik ZA, Cowdery JS, Allen LH, Harty JT, Kusner DJ, Koretzky GA. In vitro and in vivo macrophage function can occur independently of SLP-76. International Immunology 2000, 12: 887-897. PMID: 10837416, DOI: 10.1093/intimm/12.6.887.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesFc gamma RWild-type miceGamma RT cellsMacrophage functionStable chronic infectionVivo macrophage functionDownstream mediatorWild-type bone marrow-derived macrophagesFc gamma R ligationCultured bone marrow-derived macrophagesMature T cellsMarrow-derived macrophagesOxygen intermediate productionPlatelet collagen receptorAcute phaseIL-12Chronic infectionMast cellsEffector functionsIFN-gammaPhagocytic functionFc gammaR stimulation