2018
Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing
Sun Q, Rabbani P, Takeo M, Lee SH, Lim CH, Noel ES, Taketo MM, Myung P, Millar S, Ito M. Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing. Journal Of Investigative Dermatology 2018, 138: 1591-1600. PMID: 29428355, PMCID: PMC6019608, DOI: 10.1016/j.jid.2018.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCicatrixDisease Models, AnimalFemaleHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsKeratinocytesMaleMelanocytesMiceMice, TransgenicReceptors, G-Protein-CoupledRegenerationSkinSkin PigmentationStem CellsWnt ProteinsWnt Signaling PathwayWound HealingConceptsMelanocyte stem cellsMelanocyte regenerationEpidermal melanocytesStem cellsWnt ligand secretionActivation of WntWound healingSignal regulationEssential functionsWnt inhibitor Dkk1Wnt ligandsLigand secretionVital regulatorWnt pathwayTransgenic expressionWntMolecular windowΒ-cateninMelanocyte regulationInhibitor DKK1Epithelial cellsMelanocytesWound scarsRegulationAbnormal pigmentation
2014
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V. β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche. Science 2014, 343: 1353-1356. PMID: 24653033, PMCID: PMC4096864, DOI: 10.1126/science.1248373.Peer-Reviewed Original ResearchConceptsWild-type cellsWnt/β-catenin signalingΒ-catenin signalingΒ-catenin activationMouse hair follicle stem cellsΒ-cateninStem cell nicheHair follicle stem cellsFollicle stem cellsNiche signalsMutant cellsCell divisionCell nicheCoordinated regenerationHair growthWnt ligandsCellular displacementCell behaviorStem cellsHair regenerationTissue growthSignalingCellsTissue regenerationActivation
2012
Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration
Myung PS, Takeo M, Ito M, Atit RP. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration. Journal Of Investigative Dermatology 2012, 133: 31-41. PMID: 22810306, PMCID: PMC3479363, DOI: 10.1038/jid.2012.230.Peer-Reviewed Original ResearchConceptsWnt ligand secretionHair follicle epitheliumFollicle growthHair follicle growthWnt ligandsEpithelial Wnt ligandsHair cycle arrestFollicular epitheliumLigand secretionFollicle epitheliumWnt/β-catenin activationΒ-cateninAnagen inductionWnt/β-cateninStem cell markersΒ-catenin activationPotential cellular targetsHair follicle stem cellsCellular sourceCell markersHair disordersFollicle stem cellsHair folliclesEpitheliumHair follicle regeneration