2003
Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
Nichols KE, Haines K, Myung PS, Newbrough S, Myers E, Jumaa H, Shedlock DJ, Shen H, Koretzky GA. Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. Journal Of Leukocyte Biology 2003, 75: 541-552. PMID: 14694181, DOI: 10.1189/jlb.0703312.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesSLP-76SLP-65Extracellular signaling-regulated kinase 1Sheep red blood cellsInitial host defenseLow-dose infectionNumber of liverWild-type miceSrc homology 2Functional eventsMarrow-derived macrophagesTotal body burdenReceptor-mediated signalingReceptor-induced activationRed blood cellsLeukocyte-specific phosphoproteinReactive oxygen intermediatesT lymphocytesMast cellsFc receptorsMacrophage activationListeria monocytogenesHost defenseColony-forming units
2000
In vitro and in vivo macrophage function can occur independently of SLP-76
Myung PS, Clements JL, White DW, Malik ZA, Cowdery JS, Allen LH, Harty JT, Kusner DJ, Koretzky GA. In vitro and in vivo macrophage function can occur independently of SLP-76. International Immunology 2000, 12: 887-897. PMID: 10837416, DOI: 10.1093/intimm/12.6.887.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesFc gamma RWild-type miceGamma RT cellsMacrophage functionStable chronic infectionVivo macrophage functionDownstream mediatorWild-type bone marrow-derived macrophagesFc gamma R ligationCultured bone marrow-derived macrophagesMature T cellsMarrow-derived macrophagesOxygen intermediate productionPlatelet collagen receptorAcute phaseIL-12Chronic infectionMast cellsEffector functionsIFN-gammaPhagocytic functionFc gammaR stimulation