2004
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]
Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA. Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]. Journal Of Biological Chemistry 2004, 279: 15481-15490. PMID: 14722089, DOI: 10.1074/jbc.m313339200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlanineAntigens, CDAntigens, Differentiation, T-LymphocyteArginineBlotting, WesternCalciumCell LineCell LineageFlow CytometryGene DeletionGenes, DominantHematopoietic Stem CellsHumansJurkat CellsLectins, C-TypeLuciferasesLymphocyte ActivationLysineMembrane MicrodomainsModels, BiologicalMutationPhosphoproteinsPlasmidsPrecipitin TestsProlineProtein Structure, TertiarySignal TransductionSrc Homology DomainsSubcellular FractionsTime FactorsT-LymphocytesTransfectionConceptsSLP-76P1 domainSLP-76 functionProline-rich domainProline-rich regionDomain deletion mutantMultiple hematopoietic lineagesLeukocyte-specific phosphoproteinSrc homologyDeletion mutantsSignal transductionSubcellular localizationHematopoietic lineagesFunctional roleProtein fragmentsT cell receptorMolecular scaffoldsCell functionCell receptorLocalizationComplementary approachesDomainT cell functionMolecular associationDirect evidence
2003
Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
Nichols KE, Haines K, Myung PS, Newbrough S, Myers E, Jumaa H, Shedlock DJ, Shen H, Koretzky GA. Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. Journal Of Leukocyte Biology 2003, 75: 541-552. PMID: 14694181, DOI: 10.1189/jlb.0703312.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesSLP-76SLP-65Extracellular signaling-regulated kinase 1Sheep red blood cellsInitial host defenseLow-dose infectionNumber of liverWild-type miceSrc homology 2Functional eventsMarrow-derived macrophagesTotal body burdenReceptor-mediated signalingReceptor-induced activationRed blood cellsLeukocyte-specific phosphoproteinReactive oxygen intermediatesT lymphocytesMast cellsFc receptorsMacrophage activationListeria monocytogenesHost defenseColony-forming units