Differential Requirement for SLP-76 Domains in T Cell Development and Function
Myung P, Derimanov G, Jordan M, Punt J, Liu Q, Judd B, Meyers E, Sigmund C, Freedman B, Koretzky G. Differential Requirement for SLP-76 Domains in T Cell Development and Function. Immunity 2001, 15: 1011-1026. PMID: 11754821, DOI: 10.1016/s1074-7613(01)00253-9.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid MotifsAmino Acid SubstitutionAnimalsBinding SitesCalcium SignalingCarrier ProteinsCD3 ComplexCell DifferentiationClonal DeletionImmunophenotypingMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMutation, MissensePhosphoproteinsProtein Structure, TertiaryReceptors, Antigen, T-CellRecombinant Fusion ProteinsSequence DeletionSignal TransductionSpleenSrc Homology DomainsStructure-Activity RelationshipThymus GlandT-LymphocytesConceptsSLP-76T cell developmentCell developmentDifferential requirementSLP-76 functionT cell receptor signalingCell receptor signalingAdaptor proteinMolecular mechanismsNull backgroundExamination of miceReceptor signalingCell functionPeripheral T cellsNew insightsTransgenic miceStructural requirementsSpecific domainsT cell functionT cellsCellsDomainMutantsThymocytesSignalingPositive and negative regulation of t-cell activation by adaptor proteins
Koretzky G, Myung P. Positive and negative regulation of t-cell activation by adaptor proteins. Nature Reviews Immunology 2001, 1: 95-107. PMID: 11905825, DOI: 10.1038/35100523.Peer-Reviewed Original ResearchConceptsEffector protein activityPost-translational modificationsSrc family kinasesAdaptor domainsAdaptor proteinSH3 domainFamily kinasesSubcellular localizationGenetic manipulationNegative regulationProtein activityNegative regulatorAdaptorEffector moleculesT cell activationCell linesSpatial organizationRegulatorProteinIntramolecular interactionsLymphocyte activationSH2ActivationKinaseComplexes