Zyxin Is a Transforming Growth Factor-β (TGF-β)/Smad3 Target Gene That Regulates Lung Cancer Cell Motility via Integrin α5β1*
Mise N, Savai R, Yu H, Schwarz J, Kaminski N, Eickelberg O. Zyxin Is a Transforming Growth Factor-β (TGF-β)/Smad3 Target Gene That Regulates Lung Cancer Cell Motility via Integrin α5β1*. Journal Of Biological Chemistry 2012, 287: 31393-31405. PMID: 22778267, PMCID: PMC3438968, DOI: 10.1074/jbc.m112.357624.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesCell Line, TumorCell MovementFocal AdhesionsGene SilencingHumansIntegrin alpha5beta1Intercellular JunctionsLung NeoplasmsMiceMice, Mutant StrainsMicrofilament ProteinsPhosphoproteinsProto-Oncogene Proteins p21(ras)Signal TransductionSmad3 ProteinTransforming Growth Factor beta1ZyxinConceptsEpithelial-mesenchymal transitionCancer cell motilityCell motilityFocal adhesionsZyxin expressionCell-extracellular matrix adhesionLung cancer cellsFocal adhesion proteinsSingle cell motilityCell-cell junctionsCell adherens junctionsNovel functional targetSingle cell migrationLung cancer cell motilityCancer cellsNovel direct targetZyxin geneTGF-β signalingTumor suppressor effectActin cytoskeletonAdherens junctionsCytoskeletal organizationZyxinTarget genesAdhesion proteinsPlasma Proteins for Risk Prediction in Idiopathic Pulmonary Fibrosis
Richards TJ, Kaminski N, Gibson KF. Plasma Proteins for Risk Prediction in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2012, 185: 1329-1330. PMID: 22707740, PMCID: PMC5448581, DOI: 10.1164/ajrccm.185.12.1329.Peer-Reviewed Original ResearchPeripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis
Richards TJ, Kaminski N, Baribaud F, Flavin S, Brodmerkel C, Horowitz D, Li K, Choi J, Vuga LJ, Lindell KO, Klesen M, Zhang Y, Gibson KF. Peripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2012, 185: 67-76. PMID: 22016448, PMCID: PMC3262037, DOI: 10.1164/rccm.201101-0058oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCell Adhesion MoleculesCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansIdiopathic Pulmonary FibrosisIntercellular Adhesion Molecule-1Interleukin-8MaleMatrix Metalloproteinase 1Matrix Metalloproteinase 7Matrix MetalloproteinasesPredictive Value of TestsProportional Hazards ModelsS100 ProteinsS100A12 ProteinSurvival AnalysisVascular Cell Adhesion Molecule-1ConceptsIdiopathic pulmonary fibrosisTransplant-free survivalPoor transplant-free survivalPoor progression-free survivalProgression-free survivalDerivation cohortIL-8ICAM-1MMP-7Overall survivalPulmonary fibrosisValidation cohortCox proportional hazards modelVascular cell adhesion moleculeAdhesion moleculesLethal lung diseaseBead-based multiplex assayPoor overall survivalRisk prediction scoreMultiplex bead-based immunoassayAssociation of biomarkersProportional hazards modelIntercellular adhesion moleculePrioritization of patientsPlasma proteins