2021
Prediction of Survival after Chronic Lung Allograft Dysfunction in Lung Transplant Recipients by Blood Profiling Using a Predefined 52 Gene Signature
Luijk B, Krebber M, Li Q, Kardol-Hoefnagel T, Budding K, van Kessel D, Grutters J, Otten H, Kaminski N, Maya J. Prediction of Survival after Chronic Lung Allograft Dysfunction in Lung Transplant Recipients by Blood Profiling Using a Predefined 52 Gene Signature. The Journal Of Heart And Lung Transplantation 2021, 40: s155-s156. DOI: 10.1016/j.healun.2021.01.470.Peer-Reviewed Original ResearchChronic lung allograft dysfunctionDiagnosis of CLADPeripheral blood mononuclear cellsLung allograft dysfunctionAllograft dysfunctionLTx recipientsRisk groupsHigh riskRisk scoreIdiopathic pulmonary fibrosis patientsLung transplant recipientsHigh-risk patientsKaplan-Meier analysisPulmonary fibrosis patientsBlood mononuclear cellsHigh-risk groupLow-risk groupLow-risk scoresPrediction of survivalLong-term survivalCLAD onsetCLAD patientsLung transplantationTransplant recipientsOverall survival
2019
Assessing Patterns of Palliative Care Referral and Location of Death in Patients with Idiopathic Pulmonary Fibrosis: A Sixteen-Year Single-Center Retrospective Cohort Study
Zou RH, Nouraie M, Chen X, Saul MI, Kaminski N, Gibson KF, Kass DJ, Lindell KO. Assessing Patterns of Palliative Care Referral and Location of Death in Patients with Idiopathic Pulmonary Fibrosis: A Sixteen-Year Single-Center Retrospective Cohort Study. Journal Of Palliative Medicine 2019, 22: 538-544. PMID: 30615545, PMCID: PMC7869870, DOI: 10.1089/jpm.2018.0400.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisSpecialty referral centerIPF patientsPalliative careLocation of deathPC referralHospice deathsReferral centerPulmonary fibrosisLife discussionsCenter retrospective cohort studyPalliative care referralTotal outpatient visitsCharlson Comorbidity IndexRetrospective cohort studyFatal lung diseasePatient-provider relationshipComorbidity indexHospital deathSevere comorbiditiesTransplant recipientsCare referralCohort studyMedian survivalClinical factors
2015
Palliative Care and Location of Death in Decedents With Idiopathic Pulmonary Fibrosis
Lindell KO, Liang Z, Hoffman LA, Rosenzweig MQ, Saul MI, Pilewski JM, Gibson KF, Kaminski N. Palliative Care and Location of Death in Decedents With Idiopathic Pulmonary Fibrosis. CHEST Journal 2015, 147: 423-429. PMID: 25187973, PMCID: PMC4314817, DOI: 10.1378/chest.14-1127.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisLocation of deathPalliative care referralPalliative careCare referralPulmonary fibrosisAdequacy of endCommunity hospital wardsLung transplant recipientsTiming of referralMajority of patientsObituary listingsTransplant recipientsMedian survivalSymptom burdenSpecialty centersFirst visitHospital settingCenter visitsHospital wardsClinical practiceReferralPatientsDecedentsCare
2011
The HLA Class II Allele DRB1*1501 Is Over-Represented in Patients with Idiopathic Pulmonary Fibrosis
Xue J, Gochuico BR, Alawad AS, Feghali-Bostwick CA, Noth I, Nathan SD, Rosen GD, Rosas IO, Dacic S, Ocak I, Fuhrman CR, Cuenco KT, Smith MA, Jacobs SS, Zeevi A, Morel PA, Pilewski JM, Valentine VG, Gibson KF, Kaminski N, Sciurba FC, Zhang Y, Duncan SR. The HLA Class II Allele DRB1*1501 Is Over-Represented in Patients with Idiopathic Pulmonary Fibrosis. PLOS ONE 2011, 6: e14715. PMID: 21373184, PMCID: PMC3044131, DOI: 10.1371/journal.pone.0014715.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisIPF patientsIPF subjectsAmbulatory patientsPulmonary fibrosisLung diseaseHLA-DRB1Normal subjectsEtiology of IPFHuman leukocyte antigen (HLA) allele frequenciesManifestations of IPFAbnormal adaptive immune responsesLung transplantation recipientsHLA class IIAdaptive immune responsesU.S. medical centersHLA-DR locusNormal reference populationDistinct clinical phenotypesRefractory lung diseaseSpecific HLA-DRB1Lung transplantationTransplant recipientsTransplantation recipientsGrim prognosis
2010
Combinatorial Analysis Of Secreted Plasma Proteins Is Associated With Long-term Outcome In Lung Transplant Recipients
Richards T, Choi J, Zhang Y, Kaminski N, Studer S. Combinatorial Analysis Of Secreted Plasma Proteins Is Associated With Long-term Outcome In Lung Transplant Recipients. 2010, a1006-a1006. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1006.Peer-Reviewed Original Research
2003
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 8407-8411. PMID: 12815096, PMCID: PMC166242, DOI: 10.1073/pnas.1432929100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBleomycinBone Marrow TransplantationCollagenDrug ResistanceEnzyme InductionFemaleFibrosisGene Expression RegulationGraft SurvivalHydroxyprolineIn Situ Hybridization, FluorescenceLungMaleMatrix MetalloproteinasesMesodermMiceMice, Inbred BALB CMice, Inbred C57BLOsteopontinPolymerase Chain ReactionPulmonary FibrosisRNA, MessengerSialoglycoproteinsStem Cell TransplantationTransplantation, HeterotopicConceptsLung tissueMesenchymal stem cellsCollagen depositionResistant BALB/c miceMesenchymal stem cell engraftmentBALB/c miceTotal lung DNAControl-treated miceDonor-derived cellsWhole lung tissueStem cell engraftmentType II epithelial cellsTransplant recipientsC57BL/6 recipientsMSC administrationEpithelium-like morphologyFibrotic effectsIntracranial transplantationMSC transplantationC miceBleomycin exposureLung DNAMurine bone marrowReal-time PCRBone marrow