2015
A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis
Bauer Y, Tedrow J, de Bernard S, Birker-Robaczewska M, Gibson KF, Guardela BJ, Hess P, Klenk A, Lindell KO, Poirey S, Renault B, Rey M, Weber E, Nayler O, Kaminski N. A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2015, 52: 217-231. PMID: 25029475, PMCID: PMC4370242, DOI: 10.1165/rcmb.2013-0310oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisHuman idiopathic pulmonary fibrosisLung fibrosis modelGrowth factor-β1IPF lungsPulmonary fibrosisFibrosis modelFactor-β1Therapeutic interventionsDevastating lung diseasePrimary human lung fibroblastsLung Tissue Research ConsortiumGene marker setsPotential therapeutic interventionsHuman lung fibroblastsEpithelial A549 cellsHuman epithelial A549 cellsBleomycin instillationLung fibrosisControl lungsLung diseaseControl cohortControl subjectsTranslational significanceNovel treatments
2010
Have advanced research technologies made real impact on respiratory medicine?
Kjetil A, EICKELBERG O, GAULDIE J, KAMINSKI N, Martin K. Have advanced research technologies made real impact on respiratory medicine? Respirology 2010, 15: 876-880. PMID: 20646243, DOI: 10.1111/j.1440-1843.2010.01811.x.Peer-Reviewed Original ResearchConceptsGene array analysisGenetic manipulationGene expressionSystems biologyMolecular researchNovel pathwayArray analysisTremendous sophisticationDisease initiationPotential roleNovel toolAdvanced research technologiesLung diseaseRespiratory medicineHumans todayProteomicsUnique insightsGenesRNABiologyBioinformaticsProteinChronic lung diseaseTherapeutic interventionsPathway
2005
Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis
Pardo A, Gibson K, Cisneros J, Richards TJ, Yang Y, Becerril C, Yousem S, Herrera I, Ruiz V, Selman M, Kaminski N. Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis. PLOS Medicine 2005, 2: e251. PMID: 16128620, PMCID: PMC1198037, DOI: 10.1371/journal.pmed.0020251.Peer-Reviewed Original ResearchMeSH KeywordsBronchoalveolar Lavage FluidCell MovementCell ProliferationCells, CulturedEpithelial CellsExtracellular MatrixFemaleGene Expression ProfilingHumansLungMaleMatrix Metalloproteinase 1Matrix Metalloproteinase 7Middle AgedMolecular Sequence DataOsteopontinPulmonary FibrosisRecombinant ProteinsSialoglycoproteinsTissue Inhibitor of Metalloproteinase-1Up-RegulationConceptsIdiopathic pulmonary fibrosisAlveolar epithelial cellsIPF lungsMMP-7Pulmonary fibrosisEpithelial cellsHuman idiopathic pulmonary fibrosisHuman IPF lungsPrimary human lung fibroblastsMatrix metalloprotease-1 expressionMetalloprotease-1 expressionHuman lung fibroblastsIPF patientsBronchoalveolar lavageProfibrotic effectsProfibrotic roleNormal lungAlveolar epitheliumTissue inhibitorTherapeutic interventionsAnti-CD44Incurable diseaseLungMetalloprotease-1Lethal disorder
2004
The mechanisms of idiopathic pulmonary fibrosis: can we see the elephant?
Gibson K, Kaminski N. The mechanisms of idiopathic pulmonary fibrosis: can we see the elephant? Drug Discovery Today Disease Mechanisms 2004, 1: 117-122. DOI: 10.1016/j.ddmec.2004.08.002.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisPulmonary fibrosisNew therapeutic interventionsTherapeutic interventionsPathogenesis of IPFEarly-stage diseaseChronic respiratory illnessColorado Health Sciences CenterPotential new therapiesNew vessel formationNovel disease mechanismsHealth Sciences CenterMatrix metalloprotease activationStage diseaseRespiratory illnessEffective therapyLung tissueNew therapiesAnimal modelsDisease pathogenesisFibrosisPathogenesisMetalloprotease activationDisease mechanismsVessel formation
2000
Use of Oligonucleotide Arrays to Analyze Drug Toxicity
KAMINSKI N, ALLARD J, HELLER R. Use of Oligonucleotide Arrays to Analyze Drug Toxicity. Annals Of The New York Academy Of Sciences 2000, 919: 1-8. PMID: 11083091, DOI: 10.1111/j.1749-6632.2000.tb06861.x.Peer-Reviewed Original Research