2022
Integrating Gene Expression with Genome-Wide Association Summary Statistics to Identify Genes Associated with Idiopathic Pulmonary Fibrosis Survival
Hu X, Kim J, Ma S, Huang Y, Oldham J, Allen R, Molyneaux P, Joseph C, Guillen Guio B, Hernández Beeftink T, Kropski J, Lee C, Adegunsoye A, Pugashetti J, Linderholm A, Strek M, Hubbard R, Hart S, Nicholson A, Lancaster L, Lorenzo-Salazar J, Vo V, Hirani N, Whyte M, Parfrey H, Rassl D, Wallace W, Valenzi E, Zhang Y, Stockwell A, Kaminski N, Wolters P, Molina-Molina M, Martinez F, Hall I, Tobin M, Maher T, Blackwell T, Yaspan B, Jenkins R, Wain L, Flores C, Noth I, Manichaikul A. Integrating Gene Expression with Genome-Wide Association Summary Statistics to Identify Genes Associated with Idiopathic Pulmonary Fibrosis Survival. 2022, a2326-a2326. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2326.Peer-Reviewed Original Research
2016
Post-GWAS Prioritization Through Data Integration Provides Novel Insights on Chronic Obstructive Pulmonary Disease
Lu Q, Jin C, Sun J, Bowler R, Kechris K, Kaminski N, Zhao H. Post-GWAS Prioritization Through Data Integration Provides Novel Insights on Chronic Obstructive Pulmonary Disease. Statistics In Biosciences 2016, 9: 605-621. PMID: 27812370, PMCID: PMC5087812, DOI: 10.1007/s12561-016-9151-2.Peer-Reviewed Original ResearchGenome-wide association studiesFunctional annotationGenome-wide significance thresholdNovel insightsComplex human diseasesGWAS summary statisticsPotential risk locusComplex disease studiesEpigenomic annotationsGWAS signalsCOPD geneticsEnrichment analysisRisk lociIntegrative analysisAssociation studiesHuman diseasesGenetic contributionSignal prioritizationSignificance thresholdAnnotationUnprecedented opportunityBiological findingsData integrationLociSummary statistics