2021
Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
Magota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis. Molecular Brain 2021, 14: 76. PMID: 33962678, PMCID: PMC8103621, DOI: 10.1186/s13041-021-00787-6.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAdministration of MSCsSingle infusionMesenchymal stem cellsMotor functionGait abilityDisease progressionMotor neuronsRat modelLateral sclerosisBlood-spinal cord barrierSOD1G93A rat modelSpinal cord degenerateVehicle infusion groupHind limb functionALS rat modelStem cellsLimb functionVehicle infusionFatal disorderSurvival periodTherapeutic effectLocomotor activityInfusionProgressive deterioration
2020
“Chronic” State in Neural Diseases as the Target of Cellular Therapy with Mesenchymal Stem Cells
Sasaki M, Oka S, Kataoka-Sasaki Y, Kocsis JD, Honmou O. “Chronic” State in Neural Diseases as the Target of Cellular Therapy with Mesenchymal Stem Cells. World Neurosurgery 2020, 135: 375-376. PMID: 32143241, DOI: 10.1016/j.wneu.2019.12.137.Peer-Reviewed Original Research
2019
Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model
Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Suzuki J, Sasaki Y, Nagahama H, Hashi K, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model. Neuroscience 2019, 408: 361-377. PMID: 30999031, DOI: 10.1016/j.neuroscience.2019.04.018.Peer-Reviewed Original ResearchConceptsCerebral small vessel diseaseBlood-brain barrierProgressive brain atrophyVascular dementiaMesenchymal stem cellsAlzheimer's diseaseCognitive functionBrain atrophyIntravenous infusionEffects of MSCsInfused mesenchymal stem cellsSmall vessel diseaseEssential pathological featuresAccumulation of AβSpinal cord injuryBBB transport systemsStem cellsBBB functionAβ accumulationHypertensive ratsNeuronal damageFunctional recoveryVessel diseaseCord injuryPathological features
2015
Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells
Matsushita T, Lankford KL, Arroyo EJ, Sasaki M, Neyazi M, Radtke C, Kocsis JD. Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells. Experimental Neurology 2015, 267: 152-164. PMID: 25771801, DOI: 10.1016/j.expneurol.2015.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBlood-Brain BarrierCell- and Tissue-Based TherapyDisease Models, AnimalEndothelial CellsExploratory BehaviorGlial Fibrillary Acidic ProteinLocomotionMaleMesenchymal Stem CellsMicrovesselsPermeabilityRatsRats, Sprague-DawleyRats, TransgenicReceptor, Platelet-Derived Growth Factor betaSpinal Cord InjuriesTime FactorsVon Willebrand FactorConceptsSpinal cord injuryContusive spinal cord injuryBlood-spinal cord barrierBSCB leakageIntravenous infusionMesenchymal stem cellsVon Willebrand factorMSC infusionCord injurySpinal cordBlood-spinal cord barrier disruptionExperimental spinal cord injuryIntravenous MSC infusionSpinal cord barrierEx vivo optical imagingDissociation of pericytesBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsBSCB integrityBSCB permeabilityLocomotor recoveryPost-SCIBarrier disruptionAntigen expression
2010
Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor
Sasaki M, Lankford KL, Brown RJ, Ruddle NH, Kocsis JD. Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor. Glia 2010, 58: 1523-1531. PMID: 20645414, DOI: 10.1002/glia.21026.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodiesBlood-Brain BarrierCD3 ComplexDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFreund's AdjuvantInjections, SpinalLipidsMicroscopy, Electron, TransmissionMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinRatsRats, Inbred LewSpinal CordTime FactorsVascular Endothelial Growth Factor AConceptsMyelin oligodendrocyte glycoproteinVascular endothelial growth factorExperimental autoimmune encephalomyelitisIncomplete Freund's adjuvantBlood-brain barrierInflammatory demyelinating lesionsLewis ratsEndothelial growth factorDemyelinating lesionsEAE modelAutoimmune encephalomyelitisFreund's adjuvantIntraspinal injectionOligodendrocyte glycoproteinRecombinant rat myelin oligodendrocyte glycoproteinCentral nervous system locationsGrowth factorSensitized T cellsFocal experimental autoimmune encephalomyelitisRat myelin oligodendrocyte glycoproteinSite of injectionMyelin-forming cellsMOG immunizationExtensive demyelinationLymphocyte infiltration