2022
Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury
Hirota R, Sasaki M, Kataoka-Sasaki Y, Oshigiri T, Kurihara K, Fukushi R, Oka S, Ukai R, Yoshimoto M, Kocsis JD, Yamashita T, Honmou O. Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury. Journal Of Neurotrauma 2022, 39: 1665-1677. PMID: 35611987, PMCID: PMC9734021, DOI: 10.1089/neu.2022.0106.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCorticospinal tractMesenchymal stem cellsCord injurySpinal cordSpontaneous recoveryInfused mesenchymal stem cellsLimited spontaneous recoveryDorsal corticospinal tractLateral corticospinal tractStem cellsCST pathwayCST projectionsSCI inductionMSC infusionAxonal sproutingFunctional recoveryLateral funiculusIntravenous infusionAxonal tracerLesion coreMotor pathwaysFunctional improvementCircuit reorganizationMajor projections
2011
CNPase Expression in Olfactory Ensheathing Cells
Radtke C, Sasaki M, Lankford KL, Gallo V, Kocsis JD. CNPase Expression in Olfactory Ensheathing Cells. BioMed Research International 2011, 2011: 608496. PMID: 22174557, PMCID: PMC3228405, DOI: 10.1155/2011/608496.Peer-Reviewed Original ResearchConceptsOuter nerve layerOlfactory bulbNerve layerPeripheral nervesCNPase expressionOlfactory nerve axonsTransplantation of OECsSpinal cord injuryEndogenous Schwann cellsExpression of CNPaseTransplantation of olfactoryOlfactory Ensheathing CellsEnhanced green fluorescent proteinMyelination potentialCord injuryAxonal regenerationRegenerated axonsSchwann cellsTransgenic miceNerve axonsPeripheral myelinNerveCNPaseMyelinOECs
2009
Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions
Markakis EA, Sasaki M, Lankford KL, Kocsis JD. Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions. PLOS ONE 2009, 4: e7260. PMID: 19787061, PMCID: PMC2747269, DOI: 10.1371/journal.pone.0007260.Peer-Reviewed Original ResearchUnique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury
Kocsis JD, Lankford KL, Sasaki M, Radtke C. Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury. Neuroscience Letters 2009, 456: 137-142. PMID: 19429149, PMCID: PMC2713444, DOI: 10.1016/j.neulet.2008.08.093.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryLow-affinity NGF receptorSchwann cell transplantationSignificant functional improvementSpinal cord resultsOlfactory receptor axonsPrecise cellular mechanismsCord resultsCell transplantationFunctional outcomeSynaptic contactsAxonal regenerationNasal mucosaFunctional improvementSpinal cordGlial cellsOlfactory bulbReceptor axonsTrophic supportNGF receptorAnimal modelsNeural repairTherapeutic candidateOECs
2007
Remyelination of the injured spinal cord
Sasaki M, Li B, Lankford KL, Radtke C, Kocsis JD. Remyelination of the injured spinal cord. Progress In Brain Research 2007, 161: 419-433. PMID: 17618995, PMCID: PMC2605400, DOI: 10.1016/s0079-6123(06)61030-3.Peer-Reviewed Original ResearchConceptsSpinal cord injuryFunctional outcomeSpinal cordContusive spinal cord injuryLong white matter tractsPotential cell therapy candidatesWhite matter tractsMyelin-forming cellsCell therapy candidatesCord injuryCentral necrotic coreClinical studiesTherapy candidatesNecrotic coreTransplantation studiesExperimental modelCordOutcomesCellsDemyelinationRemyelinationInjuryNecrosisOECsAxons
2006
Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord
Sasaki M, Black JA, Lankford KL, Tokuno HA, Waxman SG, Kocsis JD. Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord. Journal Of Neuroscience 2006, 26: 1803-1812. PMID: 16467529, PMCID: PMC2605396, DOI: 10.1523/jneurosci.3611-05.2006.Peer-Reviewed Original ResearchConceptsDemyelinated spinal cordSpecific membrane domainsSpinal cordVoltage-gated ion channelsGreen fluorescent proteinTransplanted Olfactory Ensheathing CellsMature NodalMembrane domainsSpinal cord demyelinationOlfactory Ensheathing CellsVivo electrophysiological recordingsFluorescent proteinJuxtaparanodal domainsMolecular reconstructionIon channelsMature nodesRemyelinated axonsExtensive remyelinationUninjured axonsKv channelsDemyelinated axonsDonor ratsCentral axonsGlial cellsJuxtaparanodal region
2004
Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin
Sasaki M, Lankford KL, Zemedkun M, Kocsis JD. Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin. Journal Of Neuroscience 2004, 24: 8485-8493. PMID: 15456822, PMCID: PMC2605369, DOI: 10.1523/jneurosci.1998-04.2004.Peer-Reviewed Original ResearchConceptsSprague-DawleyOlfactory bulbTransection siteMyelinated axonsLesion zoneForm myelinOpen field locomotor behaviorAdult olfactory bulbTransection lesionTransplantation groupPattern of repairSD ratsSpinal cordLesion areaLesionsCellular elementsImproved locomotionAxonsLocomotor behaviorMyelinGFP cellsGreen fluorescent proteinCellsAnti-GFP antibodyDiscrete bundles
2000
[Remyelination by Schwann cell transplantation for CNS demyelinated axons: functional comparison with developmental myelination].
Imaizumi T, Tsushima S, Sasaki M, Akiyama Y, Hashi K. [Remyelination by Schwann cell transplantation for CNS demyelinated axons: functional comparison with developmental myelination]. Brain And Nerve 脳と神経 2000, 52: 701-7. PMID: 11002480.Peer-Reviewed Original ResearchConceptsCompound action potentialConduction velocitySC transplantationAdult ratsDemyelinated axonsHigh-frequency stimulationDay old pupsLower conduction velocityNormal adult ratsSC myelinationSpinal cordFrequency stimulationRat dorsalHistological examinationStimulus trainsTransplantationOld pupsRemyelinationAmplitude decrementAction potentialsNormal adultsAxonsRatsNormal DCsMyelination[Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons].
Imaizumi T, Lankford K, Kocsis J, Sasaki M, Akiyama Y, Hashi K. [Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons]. Brain And Nerve 脳と神経 2000, 52: 609-15. PMID: 10934721.Peer-Reviewed Original ResearchConceptsDemyelinated CNS axonsSchwann cellsBrain cellsSpinal cordConduction velocityCNS axonsAdult rat spinal cordFronto-temporal lobesRat spinal cordAdult Schwann cellsDemyelination of axonsMyelin-forming cellsBlock of conductionAdult olfactoryDemyelinated diseasesDemyelinated axonsLess myelinationHistological examinationCNS tissueTherapeutic approachesStimulus trainsDay 28Transplanted OECsAmplitude decrementRemyelination