2020
Intravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemia
Yasuda N, Sasaki M, Kataoka-Sasaki Y, Nagahama H, Kocsis JD, Kawaharada N, Honmou O. Intravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemia. Brain Research 2020, 1747: 147040. PMID: 32771405, DOI: 10.1016/j.brainres.2020.147040.Peer-Reviewed Original ResearchConceptsIschemic spinal cord injuryIntravenous infusionMesenchymal stem cellsDiffusion tensor imagingGray matterLocomotor functionTherapeutic efficacyHind limb locomotor functionGray matter volume reductionPreservation of microvasculatureSpinal cord ischemiaLeft subclavian arteryPersistent motor deficitsVehicle-treated groupSpinal cord injuryStem cellsBSCB functionISCI ratsAortic surgeryCord ischemiaDevastating complicationNeuronal lossSubclavian arteryMotor deficitsCord injury
2005
Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells
Sasaki M, Hains BC, Lankford KL, Waxman SG, Kocsis JD. Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells. Glia 2005, 53: 352-359. PMID: 16288464, PMCID: PMC2605395, DOI: 10.1002/glia.20285.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzimidazolesCell CountCell SeparationCell SurvivalCell TransplantationEnzyme-Linked Immunosorbent AssayFluorescent DyesImage Processing, Computer-AssistedImmunohistochemistryIn Situ Nick-End LabelingMotor ActivityNeuronsOlfactory PathwaysPyramidal TractsRatsSpinal Cord InjuriesStilbamidinesConceptsCorticospinal tract neuronsSpinal cordTract neuronsNeuronal lossOEC transplantationDorsal spinal cord transectionPrimary motor cortexCortical projection neuronsSpinal cord transectionTransplantation of olfactoryRat spinal cordOlfactory Ensheathing CellsApoptotic cortical neuronsBDNF levelsNeuroprotective effectsCord transectionFunctional outcomeMotor cortexNeurotrophic moleculesProjection neuronsAxonal regenerationCortical neuronsInjury zoneTransplantationOECs