2023
Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury
Kurihara K, Sasaki M, Nagahama H, Obara H, Fukushi R, Hirota R, Yoshimoto M, Teramoto A, Kocsis J, Yamashita T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury. Brain Research 2023, 1817: 148484. PMID: 37442249, DOI: 10.1016/j.brainres.2023.148484.Peer-Reviewed Original ResearchConceptsSpinal cord injuryInfusion of MSCsChronic spinal cord injuryMesenchymal stem cellsAxonal sproutingCord injuryHD-MSCsIntravenous infusionMotor functionVehicle groupWeek 6Single high-dose infusionInjection of MSCsChronic SCI ratsSingle MSC injectionGreater functional recoveryRat SCI modelSingle intravenous infusionHigh-dose infusionLimited treatment optionsGreater functional improvementSingle high doseHigh disease burdenVivo diffusion tensor imagingEx vivo diffusion tensor imaging
2021
Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia.
Takemura M, Sasaki M, Kataoka-Sasaki Y, Kiyose R, Nagahama H, Oka S, Ukai R, Yokoyama T, Kocsis J, Ueba T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia. Journal Of Neurosurgery 2021, 137: 402-411. PMID: 34861644, DOI: 10.3171/2021.8.jns21687.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionInduction of MCAOCorpus callosumMesenchymal stem cellsChronic phaseMotor functionRat modelWeek 8Vehicle groupInterhemispheric connectionsAdministration of MSCsChronic cerebral ischemia modelNeural connectionsChronic stroke modelCerebral artery occlusionChronic cerebral ischemiaIschemic lesion volumeLong-term disabilityGreater functional improvementCerebral ischemia modelEnhanced functional recoveryAnti-neurofilament antibodiesDiffusion tensorSingle systemic infusionStem cells
2011
Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells
Sasaki M, Honmou O, Radtke C, Kocsis JD. Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells. PLOS ONE 2011, 6: e26577. PMID: 22039510, PMCID: PMC3200343, DOI: 10.1371/journal.pone.0026577.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMagnetic resonance imagingM1 occlusionCollateral circulationSevere groupVenous bloodOcclusion modelMesenchymal stem cellsMiddle cerebral artery occlusion modelM1 branchNHP stroke modelsExtensive collateral circulationArtery occlusion modelPost-operative courseMCA territory infarctionGreater functional improvementLeft sylvian fissureNonhuman primate modelFronto-temporal craniotomyExperimental stroke researchAfrican green monkeysStem cellsHMSC infusionTerritory infarctionNeurological examination