2023
Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant Adverse Prognostic Factor
Hoshimaru T, Nonoguchi N, Kosaka T, Furuse M, Kawabata S, Yagi R, Kurisu Y, Kashiwagi H, Kameda M, Takami T, Kataoka-Sasaki Y, Sasaki M, Honmou O, Hiramatsu R, Wanibuchi M. Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant Adverse Prognostic Factor. Brain Sciences 2023, 13: 1477. PMID: 37891844, PMCID: PMC10605410, DOI: 10.3390/brainsci13101477.Peer-Reviewed Original ResearchActin alpha 2Malignant gliomasDistant recurrenceACTA2 expressionKD groupSmooth muscleSignificant adverse prognostic factorMode of recurrenceAlpha 2Progression-free survivalAdverse prognostic factorHuman malignant glioma cell linesMalignant glioma cell linesClinical glioma samplesGlioma cell linesPrognostic factorsBrain invasionTumor recurrenceInvasive tumorsNovel therapiesGlioma patientsSame patientRecurrenceControl groupPotential biomarkers
2016
ACTC1 as an invasion and prognosis marker in glioma.
Ohtaki S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Noshiro S, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. ACTC1 as an invasion and prognosis marker in glioma. Journal Of Neurosurgery 2016, 126: 467-475. PMID: 27081897, DOI: 10.3171/2016.1.jns152075.Peer-Reviewed Original ResearchConceptsMedian overall survivalKarnofsky Performance Scale statusTime of diagnosisMIB-1 indexGBM patientsHazard ratioPatient ageRadiological findingsKaplan-Meier methodHigh-grade gliomasReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionRemote recurrenceDistant recurrenceOverall survivalClinical featuresIndependent prognosticRecurrence rateWHO criteriaGrade IIIPolymerase chain reactionSurgical removalContralateral cerebralGrade IGrade II