2011
Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments
Sasaki M, Lankford KL, Radtke C, Honmou O, Kocsis JD. Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments. Experimental Neurology 2011, 229: 88-98. PMID: 21281634, DOI: 10.1016/j.expneurol.2011.01.010.Peer-Reviewed Original ResearchConceptsCell transplantationDemyelinated spinal cord axonsMacrophage/microglia activationMost rodent modelsEndogenous myelin repairSpinal cord axonsNervous system repairMyelin-forming cellsMicroglia activationDemyelination modelDemyelinated lesionsLesion environmentActive demyelinationMyelin repairMyelin debrisRemyelination potentialInflammatory signalingRodent modelsLesion inductionRemyelinationExperimental remyelinationTransplantationTransplant studiesOECsHuman progenitors
2008
Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells
Lankford KL, Sasaki M, Radtke C, Kocsis JD. Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells. Glia 2008, 56: 1664-1678. PMID: 18551623, DOI: 10.1002/glia.20718.Peer-Reviewed Original ResearchConceptsCentral nervous systemSpinal cordSchwann cellsOligodendrocyte progenitor cellsNormal central nervous systemMigratory propertiesOX-42 stainingNormal spinal cordOlfactory Ensheathing CellsMyelin-forming cellsDemyelinated lesionsHost axonsPhagocytic phenotypePoor survivalSubsequent lesionsNervous systemWhite matterCordLimited survivalOECsMigratory capabilityProgenitor cellsTransplantationX-irradiationLesions18 MULTIPLE SCLEROSIS: REMYELINATION
KOCSIS J, SASAKI M, LANKFORD K, RADTKE C. 18 MULTIPLE SCLEROSIS: REMYELINATION. 2008, 413-435. DOI: 10.1016/b978-012373994-0.50020-8.Peer-Reviewed Original ResearchMyelin-forming cellsMultiple sclerosisConduction abnormalitiesPotential neuroprotective effectsProminent pathological featurePeripheral nervous systemEndogenous progenitor cellsPotassium channel distributionRemyelinated axonsIon channel organizationDemyelinated lesionsNeuroprotective effectsAxonal transectionPathological featuresFunctional deficitsMyelin repairAxonal repairMyelin resultsNervous systemImpulse conductionProgenitor cellsRemyelinationSclerosisTransectionAbnormalities
2004
Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord
Oka S, Honmou O, Akiyama Y, Sasaki M, Houkin K, Hashi K, Kocsis JD. Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord. Brain Research 2004, 1030: 94-102. PMID: 15567341, DOI: 10.1016/j.brainres.2004.09.062.Peer-Reviewed Original ResearchConceptsNeural precursor cellsAutologous transplantationSpinal cordPrecursor cellsSubventricular zoneAdult primate brainMonkey spinal cordCentral nervous system axonsPresence of mitogensAdult nonhuman primatesNon-human primatesNeurological deficitsDemyelinated lesionsDorsal columnsIntraspinal injectionElectron microscopic examinationControl lesionsLesion sitePrimate brainPeripheral patternMyelinated axonsTransplantationLesionsNonhuman primatesCord