Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
Brechbuhl HM, Finlay-Schultz J, Yamamoto T, Gillen A, Cittelly DM, Tan AC, Sams SB, Pillai M, Elias A, Robinson WA, Sartorius CA, Kabos P. Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen. Clinical Cancer Research 2017, 23: 1710-1721. PMID: 27702820, PMCID: PMC5378660, DOI: 10.1158/1078-0432.ccr-15-2851.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, HormonalBreast NeoplasmsCancer-Associated FibroblastsCD146 AntigenDrug Resistance, NeoplasmEstrogensFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsReceptors, EstrogenTamoxifenTumor MicroenvironmentConceptsCancer-associated fibroblastsBreast cancer cellsBreast cancerER expressionPatient outcomesCancer cellsEstrogen receptor-positive breast cancerReceptor-positive breast cancerTamoxifen-resistant breast cancer cellsBreast cancer-associated fibroblastsInferior clinical responseMajor clinical complicationsER expression levelsEstrogen-dependent proliferationWorse patient outcomesClin Cancer ResPatient breast tumorsTumor cell sensitivityTumor cell resistanceAntiendocrine therapyTamoxifen therapyClinical responseDisease recurrenceClinical complicationsDevelopment of resistance