2024
Endothelial-adipocyte Cx43 mediated gap junctions can regulate adiposity
Luse M, Dunaway L, Nyshadham S, Carvalho A, Sedovy M, Ruddiman C, Tessema R, Hirschi K, Johnstone S, Isakson B. Endothelial-adipocyte Cx43 mediated gap junctions can regulate adiposity. Function 2024, zqae029. PMID: 38984993, DOI: 10.1093/function/zqae029.Peer-Reviewed Original ResearchHigh-fat dietHigh-fat diet miceGap junctionsIncreased risk of cardiovascular diseaseUpregulation of fatty acid-binding protein 4Co-culture transwell systemPhosphorylation of Cx43Adipose endothelial cellsRisk of cardiovascular diseaseImproved lipid profileFatty acid binding protein 4Endothelial Cx43Adipocytes in vitroAdipose tissue functionBinding protein 4Post-translational modificationsEpididymal fat padsHeterocellular contactsSingle-cell RNA sequencingEndothelial dysfunctionSerine 368Cx43Heterocellular communicationLipid profileGenetic deletion
2023
Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Genet G, Genet N, Paila U, Cain S, Cwiek A, Chavkin N, Serbulea V, Figueras A, Cerdà P, McDonnell S, Sankaranarayanan D, Huba M, Nelson E, Riera-Mestre A, Hirschi K. Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation 2023, 149: 944-962. PMID: 38126211, PMCID: PMC10954087, DOI: 10.1161/circulationaha.122.062952.Peer-Reviewed Original ResearchHereditary hemorrhagic telangiectasiaArteriovenous malformationsVascular malformationsHemorrhagic telangiectasiaCDK 4/6 inhibitor palbociclibCell cycle G1 arrestCell cycle stateG1 arrestEndothelial-specific deletionInhibitor palbociclibLate G1 arrestPalbociclib treatmentArteriovenous shuntsDrug AdministrationTherapeutic potentialGenetic deletionType 1Cell cycle controlEndothelial cell cycleMalformationsArteriovenous identityEndothelial cell migrationAVM developmentPalbociclibCycle control