2012
Short Term Interactions with Long Term Consequences: Modulation of Chimeric Vessels by Neural Progenitors
Williams C, Rauch MF, Michaud M, Robinson R, Xu H, Madri J, Lavik E. Short Term Interactions with Long Term Consequences: Modulation of Chimeric Vessels by Neural Progenitors. PLOS ONE 2012, 7: e53208. PMID: 23300890, PMCID: PMC3531360, DOI: 10.1371/journal.pone.0053208.Peer-Reviewed Original Research
2011
Characterization of the Natural History of Extracellular Matrix Production in Tissue-Engineered Vascular Grafts during Neovessel Formation
Naito Y, Williams-Fritze M, Duncan DR, Church SN, Hibino N, Madri JA, Humphrey JD, Shinoka T, Breuer CK. Characterization of the Natural History of Extracellular Matrix Production in Tissue-Engineered Vascular Grafts during Neovessel Formation. Cells Tissues Organs 2011, 195: 60-72. PMID: 21996715, PMCID: PMC3257815, DOI: 10.1159/000331405.Peer-Reviewed Original ResearchA critical role for macrophages in neovessel formation and the development of stenosis in tissue‐engineered vascular grafts
Hibino N, Yi T, Duncan DR, Rathore A, Dean E, Naito Y, Dardik A, Kyriakides T, Madri J, Pober JS, Shinoka T, Breuer CK. A critical role for macrophages in neovessel formation and the development of stenosis in tissue‐engineered vascular grafts. The FASEB Journal 2011, 25: 4253-4263. PMID: 21865316, PMCID: PMC3236622, DOI: 10.1096/fj.11-186585.Peer-Reviewed Original ResearchConceptsMacrophage infiltrationNeovessel formationGraft-related complicationsIncidence of stenosisTissue-engineered vascular graftsDevelopment of stenosisTransgenic mouse modelRole of macrophagesFirst clinical trialSmooth muscle cellsVascular graftsTEVG stenosisMacrophage infiltratesClodronate liposomesClinical trialsM1 macrophagesM2 phenotypeMurine modelMouse modelStenosisSeeded graftsRole of cellNatural historyMuscle cellsMacrophages
2008
Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood–spinal cord barrier
Rauch MF, Hynes SR, Bertram J, Redmond A, Robinson R, Williams C, Xu H, Madri JA, Lavik EB. Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood–spinal cord barrier. European Journal Of Neuroscience 2008, 29: 132-145. PMID: 19120441, PMCID: PMC2764251, DOI: 10.1111/j.1460-9568.2008.06567.x.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAnimalsBlood VesselsBlood-Brain BarrierCells, CulturedCoculture TechniquesDisease Models, AnimalEndothelial CellsFemaleGlycolatesHydrogelsLactic AcidMicrocirculationNeovascularization, PhysiologicPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleyRats, TransgenicSpinal CordSpinal Cord InjuriesStem Cell TransplantationTissue EngineeringTissue ScaffoldsTreatment OutcomeConceptsBlood-spinal cord barrierSpinal cord injuryCord injuryNeural progenitor cellsEndothelial cellsPositive stainingRat hemisection modelEndothelial barrier antigenFunctional vesselsRole of angiogenesisInjury epicenterSimilar coculturesSpinal cordNPC groupHemisection modelEC groupVessel densityLesion controlInjuryNeural regenerationProgenitor cellsAngiogenesisNeural progenitorsSubcutaneous modelCocultureCo-culture of primary neural progenitor and endothelial cells in a macroporous gel promotes stable vascular networks in vivo
Rauch MF, Michaud M, Xu H, Madri JA, Lavik EB. Co-culture of primary neural progenitor and endothelial cells in a macroporous gel promotes stable vascular networks in vivo. Journal Of Biomaterials Science Polymer Edition 2008, 19: 1469-1485. PMID: 18973724, DOI: 10.1163/156856208786140409.Peer-Reviewed Original Research
2006
A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo
Ford MC, Bertram JP, Hynes SR, Michaud M, Li Q, Young M, Segal SS, Madri JA, Lavik EB. A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 2512-2517. PMID: 16473951, PMCID: PMC1413771, DOI: 10.1073/pnas.0506020102.Peer-Reviewed Original Research