2008
Differential Effects of Shear Stress and Cyclic Strain on Sp1 Phosphorylation by Protein Kinase Cζ Modulates Membrane Type 1–Matrix Metalloproteinase in Endothelial Cells
Kim JI, Cordova AC, Hirayama Y, Madri JA, Sumpio BE. Differential Effects of Shear Stress and Cyclic Strain on Sp1 Phosphorylation by Protein Kinase Cζ Modulates Membrane Type 1–Matrix Metalloproteinase in Endothelial Cells. Endothelium 2008, 15: 33-42. PMID: 18568943, PMCID: PMC2644408, DOI: 10.1080/10623320802092260.Peer-Reviewed Original ResearchConceptsSp1 phosphorylationMT1-MMP expressionPromoter sitesPKCzeta inhibitorProtein kinase CzetaAffinity of Sp1Egr-1 bindingProtein kinase CζExtracellular matrix remodelingEndothelial cell migrationSp1Cell migrationPhosphorylationMatrix remodelingProtein expressionCyclic strainExpressionMembrane typeEndothelial cellsKey roleCzetaInhibitorsCζMetalloproteinaseAffinity
2003
The evolving roles of cell surface proteases in health and disease: Implications for developmental, adaptive, inflammatory, and neoplastic processes
Madri JA. The evolving roles of cell surface proteases in health and disease: Implications for developmental, adaptive, inflammatory, and neoplastic processes. Current Topics In Developmental Biology 2003, 54: 391-410. PMID: 12696757, DOI: 10.1016/s0070-2153(03)54016-9.Peer-Reviewed Original ResearchConceptsCell surface proteolysisCell surface proteaseSurface proteolysisSurface proteaseDiversity of enzymesExtracellular matrix remodelingMaintenance of homeostasisBiological functionsMatrix remodelingAdaptive responseNormal homeostasisProteolytic responseCell proliferationProteolysisProtease activityEnzyme systemGeneral importanceHomeostasisProteaseCell attractionVascular systemDegenerative diseasesImportant processNeoplastic processComplement system