Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes.
Bianchi E, Ferrero E, Fazioli F, Mangili F, Wang J, Bender J, Blasi F, Pardi R. Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes. Journal Of Clinical Investigation 1996, 98: 1133-1141. PMID: 8787676, PMCID: PMC507535, DOI: 10.1172/jci118896.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesBreast NeoplasmsCD18 AntigensCell MovementCyclic AMPFemaleFlow CytometryHumansImmunologic CappingIntegrin beta1Lymphocyte ActivationLymphocytes, Tumor-InfiltratingPancreatic NeoplasmsProtein Kinase CReceptors, Cell SurfaceReceptors, Urokinase Plasminogen ActivatorRNA, MessengerSecond Messenger SystemsT-LymphocytesUrokinase-Type Plasminogen ActivatorConceptsUrokinase plasminogen activatorAntigen receptor complexProtein kinase C activationAnti-uPAR antibodiesPlasminogen activator/plasmin systemKinase C activationPrimary human tumor specimensRegulated processPrimary T lymphocytesHuman tumor specimensT lymphocytesT cellsUrokinase receptorCell migrationExtracellular matrixReceptor complexC activationProtein levelsSites of inflammationT cell migrationPlasminogen activationCatalytic activationIntracellular cyclic AMPPlasmin systemCyclic AMPFeedback modulation of ligand-engaged alpha L/beta 2 leukocyte integrin (LFA-1) by cyclic AMP-dependent protein kinase.
Rovere P, Inverardi L, Bender J, Pardi R. Feedback modulation of ligand-engaged alpha L/beta 2 leukocyte integrin (LFA-1) by cyclic AMP-dependent protein kinase. The Journal Of Immunology 1996, 156: 2273-9. PMID: 8690918, DOI: 10.4049/jimmunol.156.6.2273.Peer-Reviewed Original ResearchConceptsProtein kinase CAdhesion receptorsKinase CCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseCytoskeletal anchoring proteinsIntegrin-dependent activationCAMP-dependent kinase activationIntracellular cAMP elevationCAMP elevationHeterologous cell linesLeukocyte integrinsAnchoring proteinsRegulated processProtein kinaseAdenylyl cyclase isoformsMolecular basisKinase activationIntercellular adhesionF-actinCell deadhesionHuman intercellular adhesion molecule-1LFA-1 receptorsDependent adhesionShort-term regulation