2000
Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord
Imaizumi T, Lankford K, Burton W, Fodor W, Kocsis J. Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Nature Biotechnology 2000, 18: 949-953. PMID: 10973214, PMCID: PMC2605371, DOI: 10.1038/79432.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsCD59 AntigensCell SeparationElectrophysiologyFlow CytometryFluorescent Antibody Technique, IndirectHumansImmunosuppression TherapyModels, BiologicalOlfactory NerveRatsRats, WistarRegenerationSchwann CellsSciatic NerveSpinal CordSwineTransgenesTransplantation, HeterologousConceptsAxonal regenerationSpinal cordSchwann cellsImpulse conductionLesion-control ratsDorsal column lesionTransplantation of olfactoryRat spinal cordConduction velocity measurementsComplement inhibitory proteinsHyperacute responseRegenerated axonsImmunosuppressed ratsTransection siteLesion sitePeripheral patternHost tractCordNormal axonsDonor cellsAxonsInhibitory proteinRatsDonor cell typeTransgenic pigs
1994
Intracellular calcium mobilization and neurite outgrowth in mammalian neurons
Kocsis J, Rand M, Lankford K, Waxman S. Intracellular calcium mobilization and neurite outgrowth in mammalian neurons. Developmental Neurobiology 1994, 25: 252-264. PMID: 8195789, DOI: 10.1002/neu.480250306.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCaffeineCalciumCalcium ChannelsCell CompartmentationCell DifferentiationCells, CulturedFemaleGanglia, SpinalGene Expression RegulationImage Processing, Computer-AssistedIntracellular FluidIon Channel GatingLasersMicroscopy, FluorescenceModels, BiologicalNeuritesNeuronsRatsRats, WistarTerpenesThapsigarginConceptsDepolarization-induced Ca2Calcium-induced calcium releaseDRG neuronsIntracellular Ca2Cultured adult rat dorsal root ganglion neuronsAdult rat dorsal root ganglion neuronsRat dorsal root ganglion neuronsNeurite outgrowthDorsal root ganglion neuronsIntact intracellular Ca2Intracellular calcium mobilizationIndicator dye fluo-3Nuclear Ca2Dye Fluo-3Endoplasmic reticulum Ca2Ganglion neuronsCalcium mobilizationDependent kinase IICalcium releaseFluo-3NeuronsMammalian neuronsReticulum Ca2Elevated Ca2Elicit neurite outgrowth
1992
A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons
Pongracz F, Poolos N, Kocsis J, Shepherd G. A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons. Journal Of Neurophysiology 1992, 68: 2248-2259. PMID: 1337105, PMCID: PMC2605954, DOI: 10.1152/jn.1992.68.6.2248.Peer-Reviewed Original ResearchConceptsReceptor-mediated conductanceExcitatory postsynaptic potentialsPyramidal neuronsSynaptic responsesSynaptic activationSize of EPSPsExtracellular ion concentration changesNMDA receptor-mediated activityCA1 hippocampal pyramidal cellsCA1 hippocampal pyramidal neuronsHippocampal CA1 pyramidal neuronsDendritic NMDA receptorsRepetitive synaptic activationCA1 pyramidal neuronsInhibitory synaptic responsesFrequency-dependent depressionHippocampal pyramidal neuronsNMDA receptor activationHippocampal pyramidal cellsExtracellular potassium accumulationRepetitive activityIntrinsic membrane conductancesReceptor-mediated activityHz. 4Spike afterdepolarization