1998
The delayed depolarization in rat cutaneous afferent axons is reduced following nerve transection and ligation, but not crush: Implications for injury‐induced axonal NA + channel reorganization
Sakai J, Honmou O, Kocsis J, Hashi K. The delayed depolarization in rat cutaneous afferent axons is reduced following nerve transection and ligation, but not crush: Implications for injury‐induced axonal NA + channel reorganization. Muscle & Nerve 1998, 21: 1040-1047. PMID: 9655122, DOI: 10.1002/(sici)1097-4598(199808)21:8<1040::aid-mus8>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsCutaneous afferent axonsNerve injurySural nerveNerve transectionAfferent axonsAction potentialsCell bodiesCutaneous afferent neuronsPeripheral nerve injuryAfferent cell bodiesSucrose gap chamberRat sural nerveTarget disconnectionAfferent neuronsPeripheral targetsAxonal NaNerveRefractory periodAxonsTransectionCompound actionDepolarizationSimilar changesInjuryTarget connectionsMorphologically Identified Cutaneous Afferent DRG Neurons Express Three Different Potassium Currents in Varying Proportions
Everill B, Rizzo M, Kocsis J. Morphologically Identified Cutaneous Afferent DRG Neurons Express Three Different Potassium Currents in Varying Proportions. Journal Of Neurophysiology 1998, 79: 1814-1824. PMID: 9535950, PMCID: PMC2605378, DOI: 10.1152/jn.1998.79.4.1814.Peer-Reviewed Original ResearchConceptsDRG neuronsMedium-sized DRG neuronsDorsal root ganglion neuronsCutaneous afferent neuronsDifferent potassium currentsWhole-cell patch-clamp configurationOutward current componentPatch-clamp configurationAfferent neuronsFluoro-GoldGanglion neuronsRetrograde labelingConditioning prepulseEntire populationChannel blockersPotassium currentMyelinated axonsSustained currentNeuronsTest pulseDendrotoxinBasis of sensitivityIKCellsBlockers
1993
Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury
Utzschneider D, Bhisitkhul R, Kocsis J. Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury. Muscle & Nerve 1993, 16: 958-963. PMID: 8355727, DOI: 10.1002/mus.880160912.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal root axonsNerve injuryDorsal rootsPotassium channel blockerAction potentialsSciatic nerveChannel blockersSpike adaptationSciatic nerve injuryPeripheral nerve injurySucrose gap chamberBrief tetanic stimulationDorsal root fibersWhole nerve recordingsSpike frequency adaptationTransection groupBurst dischargesTetanic stimulationNerve recordingsControl groupInjuryRoot fibersBurst responseNerve
1992
Conduction properties of spinal cord axons in the myelin-deficient rat mutant
Utzschneider D, Black J, Kocsis J. Conduction properties of spinal cord axons in the myelin-deficient rat mutant. Neuroscience 1992, 49: 221-228. PMID: 1407548, DOI: 10.1016/0306-4522(92)90090-o.Peer-Reviewed Original ResearchConceptsDorsal column axonsMyelin-deficient rat mutantsSpinal cordFrequency-dependent conduction blockNormal age-matched ratsBrain slice chamberMyelin-deficient rat spinal cordAction potential dischargeRat mutantAge-matched ratsRat spinal cordSpinal cord axonsAction potential conductionControl ratsDemyelinated axonsConduction blockConduction velocityRefractory periodPotential dischargeControl axonsSlice chamberPharmacological resultsPotential conductionAxonsCompensatory mechanisms
1991
Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve
Gardon T, Kocsis J, Waxman S. Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve. Muscle & Nerve 1991, 14: 640-646. PMID: 1922170, DOI: 10.1002/mus.880140707.Peer-Reviewed Original ResearchConceptsCompound action potentialRat sciatic nerveNerve crushRegenerated axonsSciatic nerveRegenerated nervesInward rectificationIntra-axonal recording techniquesAdult rat sciatic nerveTEA-sensitive potassium channelsPotassium channelsRegenerated rat sciatic nerveSucrose gap recordingsSciatic nerve crushPeripheral nerve axonsWhole nerve recordingsIntra-axonal recordingsVoltage-sensitive sodium channelsCrush injuryNormal nervesSensitive relaxationRepetitive stimulationAfterhyperpolarizationGap recordingsNerve recordings
1989
Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve
Gordon T, Kocsis J, Waxman S. Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve. Brain Research 1989, 502: 252-257. PMID: 2555026, DOI: 10.1016/0006-8993(89)90620-3.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsFemaleMembrane PotentialsNeural InhibitionOptic NerveRatsRats, Inbred StrainsTetraethylammonium CompoundsConceptsRat optic nerveOptic nerveEarly afterhyperpolarizationPharmacological sensitivityAction potentialsPeak latencyAction potential broadeningConstant current depolarizationSucrose gap chamberPotassium channel blockerLate afterhyperpolarizationChannel blockersRepetitive stimulationAfterhyperpolarizationNervePotassium conductanceSucrose gapTetraethylammoniumPotential broadeningCurrent depolarizationDepolarizationDurationApaminBlockersCharybdotoxin
1987
Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers
Bowe C, Kocsis J, Targ E, Waxman S. Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers. Annals Of Neurology 1987, 22: 264-268. PMID: 2821876, DOI: 10.1002/ana.410220212.Peer-Reviewed Original ResearchConceptsSensory fibersClinical trialsAction potentialsPotassium channel blockadeDorsal root axonsCompound action potentialDorsal spinal rootsSingle action potentialMammalian motorIntrathecal injectionMultiple sclerosisSensory dysfunctionVentral rootsSpinal rootsNeuromuscular disordersSpecific fiber typesElectrophysiological responsesSingle stimulusPhysiological effectsTrialsFiber typesResponseParesthesiaSclerosisDysfunction
1985
Myelin sheath remodelling in regenerated rat sciatic nerve
Hildebrand C, Kocsis J, Berglund S, Waxman S. Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Research 1985, 358: 163-170. PMID: 2416385, DOI: 10.1016/0006-8993(85)90960-6.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesAdult rat sciatic nerveRegenerated rat sciatic nerveNormal control nervesLight microscopic examinationAction potential waveformCrush lesionMonths survivalNerve segmentsControl nervesSame nerveIndividual nervesNerve fibersNerveShort sheathMyelin layersMyelin sheathPotassium channelsMicroscopic examinationAminopyridine-sensitivity of spinal cord white matter studied in vitro
Kocsis J. Aminopyridine-sensitivity of spinal cord white matter studied in vitro. Experimental Brain Research 1985, 57: 620-624. PMID: 2984039, DOI: 10.1007/bf00237849.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAction PotentialsAminopyridinesAnimalsIn Vitro TechniquesRatsRats, Inbred StrainsSpinal CordConceptsCentral nervous system extensionSpinal cord white matterAction potential dischargeDorsal column axonsSucrose gap chamberCompound action potentialPeripheral nervous systemCord white matterVentral root fibersAction potential characteristicsSensory fibersDorsal columnsDorsal rootsSpinal cordNervous systemWhite matterAction potentialsPotential dischargeRoot fibersPotassium channelsCourse of maturationOcclusion experimentsAxonsPronounced increaseCordLigature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spike
1983
Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents
Kocsis J, Waxman S. Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents. Nature 1983, 304: 640-642. PMID: 6308475, DOI: 10.1038/304640a0.Peer-Reviewed Original ResearchConceptsNerve fibersPotassium channelsMyelinated peripheral nerve fibresAxon segmentsPeripheral nerve fibersAxon sproutsEndoneurial tubesNerve crushFunctional recoveryFunctional organizationMyelinated fibersAxon cylindersSchwann cellsBurst activityMyelinated axonsMammalian axonsAxonsPeripheral connectionsMembrane depolarizationBasement membraneK channelsRegenerated fibersAxon maturationEffects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum
Preston R, Waxman S, Kocsis J. Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum. Experimental Neurology 1983, 79: 808-820. PMID: 6825765, DOI: 10.1016/0014-4886(83)90044-4.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAction PotentialsAminopyridinesAnimalsAxonsCorpus CallosumElectric ConductivityFemaleRatsRats, Inbred StrainsConceptsRat corpus callosumCallosal fibersCerebral axonsNerve fibersCorpus callosumMammalian peripheral nerve fibersNegative waveVoltage-dependent potassium currentsSecond negative waveNon-myelinated nerve fibresPeripheral nerve fibersField potentialsShort-latency wavesFirst negative waveCallosal stimulationPotassium blockersPotassium currentAction potentialsPeripheral fibersCallosumRecording electrodesMembrane repolarizationAxonsFunctional organizationComparable differences