1993
Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury
Utzschneider D, Bhisitkhul R, Kocsis J. Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury. Muscle & Nerve 1993, 16: 958-963. PMID: 8355727, DOI: 10.1002/mus.880160912.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal root axonsNerve injuryDorsal rootsPotassium channel blockerAction potentialsSciatic nerveChannel blockersSpike adaptationSciatic nerve injuryPeripheral nerve injurySucrose gap chamberBrief tetanic stimulationDorsal root fibersWhole nerve recordingsSpike frequency adaptationTransection groupBurst dischargesTetanic stimulationNerve recordingsControl groupInjuryRoot fibersBurst responseNerve
1991
Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve
Gardon T, Kocsis J, Waxman S. Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve. Muscle & Nerve 1991, 14: 640-646. PMID: 1922170, DOI: 10.1002/mus.880140707.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsAxonsElectric StimulationNerve RegenerationPotassium ChannelsRatsRats, Inbred StrainsSciatic NerveTetraethylammoniumTetraethylammonium CompoundsConceptsCompound action potentialRat sciatic nerveNerve crushRegenerated axonsSciatic nerveRegenerated nervesInward rectificationIntra-axonal recording techniquesAdult rat sciatic nerveTEA-sensitive potassium channelsPotassium channelsRegenerated rat sciatic nerveSucrose gap recordingsSciatic nerve crushPeripheral nerve axonsWhole nerve recordingsIntra-axonal recordingsVoltage-sensitive sodium channelsCrush injuryNormal nervesSensitive relaxationRepetitive stimulationAfterhyperpolarizationGap recordingsNerve recordings
1990
Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus
Poolos N, Kocsis J. Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus. Brain Research 1990, 508: 7-12. PMID: 2159824, DOI: 10.1016/0006-8993(90)91110-3.Peer-Reviewed Original ResearchConceptsNMDA receptor activationNMDA receptorsReceptor activationNMDA receptor-mediated componentN-methyl-D-aspartate receptorsElevated extracellular potassium concentrationReceptor-mediated componentReceptor-mediated conductanceChannel blocker tetraethylammoniumCentral nervous systemExtracellular potassium concentrationExtracellular potassium ion concentrationSlowed repolarizationOrthodromic stimulationPotassium equilibrium potentialCA1 regionPyramidal cellsRat hippocampusSynaptic activationBlocker tetraethylammoniumPostsynaptic activityRepetitive stimulationNeuronal activityNervous systemReceptors
1989
Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve
Gordon T, Kocsis J, Waxman S. Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve. Brain Research 1989, 502: 252-257. PMID: 2555026, DOI: 10.1016/0006-8993(89)90620-3.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsFemaleMembrane PotentialsNeural InhibitionOptic NerveRatsRats, Inbred StrainsTetraethylammonium CompoundsConceptsRat optic nerveOptic nerveEarly afterhyperpolarizationPharmacological sensitivityAction potentialsPeak latencyAction potential broadeningConstant current depolarizationSucrose gap chamberPotassium channel blockerLate afterhyperpolarizationChannel blockersRepetitive stimulationAfterhyperpolarizationNervePotassium conductanceSucrose gapTetraethylammoniumPotential broadeningCurrent depolarizationDepolarizationDurationApaminBlockersCharybdotoxin
1985
Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation
Bowe C, Kocsis J, Waxman S. Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation. Proceedings Of The Royal Society B 1985, 224: 355-366. PMID: 2410932, DOI: 10.1098/rspb.1985.0037.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgingAnimalsGanglia, SpinalIon ChannelsMotor NeuronsNeurons, AfferentPotassiumRatsRats, Inbred StrainsSpinal Nerve RootsTetraethylammoniumTetraethylammonium CompoundsConceptsDorsal spinal rootsSensory fibersMammalian motorPotassium channelsSpinal rootsAction potentialsRoot fibersCompound action potentialSingle sensory fibresDorsal root fibersVentral root fibersClasses of axonsIndividual action potentialsPharmacological blockadeVentral rootsYoung rootsSensory axonsWhole nervePotassium conductanceAxon responsesCourse of maturationBlockadeAxonsRoots resultsDifferential sensitivity
1980
Absence of potassium conductance in central myelinated axons
Kocsis J, Waxman S. Absence of potassium conductance in central myelinated axons. Nature 1980, 287: 348-349. PMID: 7421994, DOI: 10.1038/287348a0.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAminopyridinesAnimalsElectric ConductivityNerve Fibers, MyelinatedPotassiumRatsSpinal CordTetraethylammonium CompoundsConceptsCentral myelinated axonsMyelinated axonsAction potentialsPotassium conductanceDorsal column axonsVoltage-clamp experimentsLate outward currentOutward currentsAxonsSodium ion permeabilityLate increaseDepolarization phasePotassium permeabilityAxonal membraneRepolarizationMyelinInitial increaseVoltage-dependent changesSodium inactivationDemyelinationPrevious studies